Results 71 to 80 of about 2,068,957 (306)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Detecting financial sustainability risk of the assets using MAMDANI fuzzy controller

Technological and Economic Development of Economy, 2019
The paper aims to develop a MAMDANI fuzzy controller for detecting the financial sustainability risk of the assets owned by the company. This type of risk indicates when an asset no longer produces economic benefits to the company, or the benefits are ...
Marcel-Ioan Boloș, Ioana-Alexandra Bradea, Claudia Diana Sabău-Popa, Laurențiu-Andrei Ilie   +3 more
doaj   +1 more source

Valuation of boundary-linked assets [PDF]

, 2004
This article studies the valuation of boundary-linked assets and their derivatives in continuous-time markets. Valuing boundary-linked assets requires the solution of a stochastic differential equation with boundary conditions, which, often, is not ...
Esteban-Bravo, Mercedes, Vidal-Sanz, Jose M.   +1 more
core   +1 more source

Supporting group maintenance through prognostics-enhanced dynamic dependability prediction [PDF]

, 2017
Condition-based maintenance strategies adapt maintenance planning through the integration of online condition monitoring of assets. The accuracy and cost-effectiveness of these strategies can be improved by integrating prognostics predictions and ...
Aizpurua, J. I., Aizpurua, Jose Ignacio, Catterson, V. M., Catterson, Victoria, Chiacchio, F., Chiacchio, Ferdinando, D'Urso, D., D'Urso, Diego, Papadopoulos, Y., Papadopoulos, Yiannis   +9 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimization of Insurance Brokerage Institutions in Realizing the Trust of the Indonesian Community

Media Iuris
Public trust in the Indonesian insurance business is shaken by the crisis that rocked multiple insurance companies. This study investigates insurance brokerage institutions’ involvement in Indonesia’s insurance activities and how to improve public trust.
Elisatris Gultom, Siti Rohani, Huta Disyon   +2 more
doaj   +1 more source

INTERNATIONAL INVESTMENT POSITION OF THE REPUBLIC OF MOLDOVA [PDF]

Economica, 2020
Investment activity in the Republic of Moldova is the most important factor that determines the socio-economic development of the country. Attracting foreign direct investments remains a current task, the effective solution of which depends on the ...
Rodica BURBULEA, Elena MOROI, Lilia ȘARGU   +2 more
doaj  

Consumption, wealth, stock and housing returns: Evidence from emerging markets [PDF]

, 2011
Copyright @ 2011 Brunel UniversityIn this paper, we show, using the consumer's budget constraint, that the residuals of the trend relationship among consumption, aggregate wealth, and labour income should predict both stock returns and housing returns ...
Caporale, GM, Sousa, RM
core   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source