Results 41 to 50 of about 1,041,057 (262)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Health Technology Assessment of Assistance Dogs and Dog-Assisted Interventions
, 2020 Dogs as an assistive aid for people with disabilities date as far back in time as the first century CE. Today, dogs are used in various settings to help and assist humans. ‘Assistance dogs’ is an umbrella term for guide dogs, hearing dogs and service dogs.
openaire +4 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Exploring assistive technology for assistance dog owners in emergency situations [PDF]
Proceedings of the 8th ACM International Conference on PErvasive Technologies Related to Assistive Environments, 2015 Many vulnerable individuals own an assistance dog. Previous work has shown that a domestic alarm, Ringsel, allows assistance dogs to "call for help" via a canine interface that they interact with by pulling a detachment off with their mouths. Here we discuss the potential for systems like the Ringsel to leverage distinct behavioral patterns exhibited ...
Charlotte L. Robinson +4 more
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Frontiers in Veterinary Science, 2019 Assistance dogs can greatly improve the lives of people with disabilities. However, a large proportion of dogs bred and trained for this purpose are deemed unable to successfully fulfill the behavioral demands of this role.
Emily E. Bray +7 more
doaj +1 more source
Quantifying canine interactions with smart toys assesses suitability for service dog work
Frontiers in Veterinary Science, 2022 There are approximately a half million active service dogs in the United States, providing life-changing assistance and independence to people with a wide range of disabilities.
Ceara Byrne +2 more
doaj +1 more source
A Dog Is a Doctor’s Best Friend: The Use of a Service Dog as a Perioperative Assistant [PDF]
Case Reports in Pediatrics, 2016 Service dogs are beneficial in providing assistance to people with multiple types of disabilities and medical disorders including visual impairment, physical disabilities, seizure disorders, diabetes, and mental illness. Some service animals have been trained as a screening tool for cancer.
Shannon Tew, Brad M. Taicher
openaire +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Canine POMC deletion (P187fs) allele frequency in Labrador Retrievers in Brazil [PDF]
Pesquisa Veterinária Brasileira, 2019 : The Labrador Retriever is among the main breeds with the greatest predisposition to obesity. Several factors, especially the interrelationships between food management, exercise and social factors; influence the likelihood of a dog becoming obese ...
Natalia O. Lourenço +7 more
doaj +1 more source