Results 141 to 150 of about 1,666,748 (315)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Traumatic hyphaema following successive vacuum and forceps-assisted delivery [PDF]
, 2006 Hyphaema can cause corneal staining and is a potential risk for glaucoma. We report a case of a neonate with isolated traumatic hyphaema following a prolonged delivery with the consecutive use of vacuum and forceps.
Lipton, Jonathan +2 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Drug Design, Development and TherapyXiuxian Zhu,1– 3,* Jingwen Lang,1,2,* Yunqing Zhi,1,2 Qiaoling Wang,1,2 Yonglun Fu1– 3 1Department of Assisted Reproductive Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s ...
Zhu X, Lang J, Zhi Y, Wang Q, Fu Y
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2007 In this contribution, a nonlinear hybrid detection scheme based on a novel soft-information assisted Genetic Algorithm (GA) is proposed for a Turbo Convolutional (TC) coded Space Division Multiplexing (SDM) aided Orthogonal Frequency Division ...
Akhtman, Jos, Jiang, Ming, Hanzo, Lajos
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
2012 Assisted Reproductive Technology Report \u2014 Graphs and Charts
Graphs and charts from the 2012 Assisted Reproductive Technology National Summary Report provide an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics.
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Palliative Care and Assisted Dying Laws [PDF]
Proposals are being developed in Scotland, the Isle of Man and Jersey to allow assisted dying for people who are terminally ill, if they request it. Some people oppose legalization because of fears about the effects that assisted dying laws might have on
Gill, Michael +4 more
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