Results 91 to 100 of about 2,641,039 (362)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Assisted circulation [PDF]

, 2018
No ...
Wilson, Vernon
core   +1 more source

2019 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations : summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces

, 2019
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science.
Aickin, R, Andersen, LW, Atkins, DL, Aziz, K, Bendall, J, Berg, KM, Berry, DC, Bhanji, F, Bigham, BL, Bingham, R, Borra, V, Bray, JE, Breckwoldt, J, Brooks, SC, Buick, J, Böttiger, BW, Callaway, CW, Carlson, JN, Cassan, P, Castrén, M, Chang, WT, Charlton, NP, Cheng, A, Chung, SP, Considine, J, Couper, K, Couto, TB, Dainty, KN, Dawson, JA, de Almeida, MF, de Caen, AR, Deakin, CD, Donnino, MW, Drennan, IR, Duff, JP, Epstein, JL, Escalante, R, Fran Hazinski, M, Gazmuri, RJ, Gilfoyle, E, Granfeldt, A, Greif, R, Guerguerian, AM, Guinsburg, R, Hatanaka, T, Holmberg, MJ, Hood, N, Hosono, S, Hsieh, MJ, Isayama, T, Iwami, T, Jensen, JL, Kapadia, V, Kim, HS, Kleinman, ME, Kudenchuk, PJ, Lang, E, Lavonas, E, Liley, H, Lim, SH, Lockey, A, Lofgren, B, Ma, MH, Maconochie, I, Mancini, ME, Markenson, D, Meaney, PA, Meyran, D, Mildenhall, L, Monsieurs, KG, Montgomery, W, Morley, PT, Morrison, LJ, Nadkarni, VM, Nation, K, Neumar, RW, Ng, KC, Nicholson, T, Nikolaou, N, Nishiyama, C, Nolan, JP, Nuthall, G, O'Neil, B, Ohshimo, S, Okamoto, D, Olasveengen, TM, Paiva, EF, Parr, M, Pellegrino, JL, Perkins, GD, Perlman, J, Rabi, Y, Reis, A, Reynolds, JC, Ristagno, G, Roehr, CC, Sakamoto, T, Sandroni, C, Schexnayder, SM, Scholefield, BR, Shimizu, N, Singletary, EM, Skrifvars, MB, Smyth, MA, Soar, J, Stanton, D, Swain, J, Szyld, E, Tijssen, J, Travers, A, Trevisanuto, D, Vaillancourt, C, Van de Voorde, Patrick, Velaphi, S, Wang, TL, Weiner, G, Welsford, M, Woodin, JA, Wyckoff, MH, Wyllie, JP, Yeung, J, Yong-Kwang Ong, G, Zideman, D   +122 more
core   +1 more source

Supercapacitor assisted low dropout regulators (SCALDO) with reduced switches: A new approach to high efficiency VRM designs [PDF]

, 2013
Supercapacitor assisted low dropout (SCALDO) regulator is a new approach to develop high efficiency DC-DC converters with supercapacitors used for energy recovery.
Kularatna, Nihal, Wickramasinghe, Thilini Chintha Prabha Kumari   +1 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients

Journal of Interventional Cardiology, 2020
Background. Nicorandil in reducing contrast-induced nephropathy (CIN) following elective percutaneous coronary intervention (PCI) is an inconsistent practice.
Bin Yi, Shaoyan Mo, Yumei Jiang, Dingwu Yi, Jinwen Luo, Xiang Chen, Jian Rong   +6 more
doaj   +1 more source

Assessment of the peripheral microcirculation using computer-assisted venous congestion plethysmography in post-traumatic complex regional pain syndrome type I [PDF]

, 2001
In complex regional pain syndrome type I (CRPS-I), edema of the affected limb is a common finding. Therefore, the changes in macro- and microcirculatory parameters were investigated to elucidate the underlying pathophysiology.
Christ, Frank, Gradl, Georg, Schürmann, Matthias, Wipfel, Alexander, Zaspel, Johannes   +4 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Weight Change and Mortality Risk in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Aims: The aim of the study was to determine the associations of weight loss or gain with all-cause mortality risk in heart failure with preserved ejection fraction (HFpEF).Methods and Results: Non-lean patients from the Americas from the Treatment of ...
Peisen Huang, Peisen Huang, Peisen Huang, Zejun Guo, Weihao Liang, Weihao Liang, Weihao Liang, Yuzhong Wu, Yuzhong Wu, Yuzhong Wu, Jingjing Zhao, Jingjing Zhao, Jingjing Zhao, Xin He, Xin He, Xin He, Wengen Zhu, Wengen Zhu, Wengen Zhu, Chen Liu, Chen Liu, Chen Liu, Yugang Dong, Yugang Dong, Yugang Dong, Yuan Yu, Yuan Yu, Bin Dong, Bin Dong, Bin Dong   +29 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source