Results 91 to 100 of about 2,652,227 (388)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Weight Change and Mortality Risk in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Aims: The aim of the study was to determine the associations of weight loss or gain with all-cause mortality risk in heart failure with preserved ejection fraction (HFpEF).Methods and Results: Non-lean patients from the Americas from the Treatment of ...
Peisen Huang, Peisen Huang, Peisen Huang, Zejun Guo, Weihao Liang, Weihao Liang, Weihao Liang, Yuzhong Wu, Yuzhong Wu, Yuzhong Wu, Jingjing Zhao, Jingjing Zhao, Jingjing Zhao, Xin He, Xin He, Xin He, Wengen Zhu, Wengen Zhu, Wengen Zhu, Chen Liu, Chen Liu, Chen Liu, Yugang Dong, Yugang Dong, Yugang Dong, Yuan Yu, Yuan Yu, Bin Dong, Bin Dong, Bin Dong   +29 more
doaj   +1 more source

Intersections and differentiations: a corpus-assisted discourse study of gender representations in the British press before, during and after the London Olympics 2012 [PDF]

, 2017
This study examines the impact of a global sports event on gender representations in media reporting. Whereas previous research on gender, sport and media has been mainly concerned with sports events in the North American or Australian context, this ...
Hunt, Sally, Jaworska, Sylvia
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Association of Body-Weight Fluctuation With Outcomes in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Aims: To investigate the relationship between body-weight fluctuation and risks of clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).Methods and Results:We measured intra-individual variations in body weight from ...
Yi Li, Yi Li, Yi Li, Yuan Yu, Yuan Yu, Yuzhong Wu, Yuzhong Wu, Yuzhong Wu, Weihao Liang, Weihao Liang, Weihao Liang, Bin Dong, Bin Dong, Bin Dong, Ruicong Xue, Ruicong Xue, Ruicong Xue, Yugang Dong, Yugang Dong, Yugang Dong, Wengen Zhu, Wengen Zhu, Wengen Zhu, Peisen Huang, Peisen Huang, Peisen Huang   +25 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Accuracy of Length of Virtual Stents in Treatment of Intracranial Wide-Necked Aneurysms. [PDF]

, 2019
Background and purposePrecise stent deployment is important for successful treatment of intracranial aneurysms by stent-assisted coiling (SAC). We evaluated the accuracy of virtual stents generated using commercial stent planning software by comparing ...
Dahmani, Chihebeddine, Ishibashi, Toshihiro, Kaku, Shogo, Mohamed, Ashraf, Murayama, Yuichi, Nishimura, Kengo, Otani, Katharina, Takao, Hiroyuki, Yuki, Ichiro   +8 more
core  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Predicting influenza H3N2 vaccine efficacy from evolution of the dominant epitope [PDF]

arXiv, 2018
We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and candidate vaccine viruses based on amino acid substitutions in the dominant epitopes. In 2016-2017, our model predicts 19% efficacy compared to 20% observed.
arxiv