Results 61 to 70 of about 371,081 (303)

Focused ultrasound-enabled brain tumor liquid biopsy [PDF]

, 2018
Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors.
Chen, Hong, Cheng, Galen, Dunn, Gavin P., Leuthardt, Eric C., Liu, Weijun, Nazeri, Arash, Petti, Allegra A., Wang, Xiaowei, Ye, Dezhuang, Yue, Yimei, Zhu, Lifei   +10 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

Frontiers in Cardiovascular Medicine
BackgroundThere is growing evidence that genetic factors may play a crucial role in the development of ventricular fibrillation (VF) following acute ST-segment elevation myocardial infarction (STEMI).
Ying-Ying Ji, Ying-Ying Ji, Yang Wu, Yang Wu, Ji Sun, Ji Sun, Xiao-Xiong Lin, Xiao-Xiong Lin, Xu-Miao Chen, Xu-Miao Chen, Cheng-Cheng Ji, Cheng-Cheng Ji, Li-Juan Liu, Li-Juan Liu, Yun-Jiu Cheng, Su-Hua Wu, Su-Hua Wu   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stent-assisted reconstructive endovascular repair of intracranial aneurysms: long-term clinical and angiographic follow-up [PDF]

, 2012
Background and Purpose: The development of self-expanding stents dedicated to intracranial use has significantly widened the applicability of endovascular therapy to many intracranial aneurysms.
VANNUCCI, STEFANO
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Accuracy of Length of Virtual Stents in Treatment of Intracranial Wide-Necked Aneurysms. [PDF]

, 2019
Background and purposePrecise stent deployment is important for successful treatment of intracranial aneurysms by stent-assisted coiling (SAC). We evaluated the accuracy of virtual stents generated using commercial stent planning software by comparing ...
Dahmani, Chihebeddine, Ishibashi, Toshihiro, Kaku, Shogo, Mohamed, Ashraf, Murayama, Yuichi, Nishimura, Kengo, Otani, Katharina, Takao, Hiroyuki, Yuki, Ichiro   +8 more
core  

Utility of 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines in HIV-Infected Adults With Carotid Atherosclerosis. [PDF]

, 2017
BackgroundAlthough HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins.
Deeks, Steven, Hsue, Priscilla, Hur, Sophia, Kalapus, SC, Li, Danny, Ma, Yifei, Phan, Binh An P, Scherzer, Rebecca, Weigel, Bernard   +8 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Interleukin-6 as a novel biomarker for the diagnosis of acute decompensated heart failure: a retrospective study

Frontiers in Cardiovascular Medicine
BackgroundInterleukin-6 (IL-6) is associated with the pathogenesis of heart failure (HF) and an increased HF risk in people without previous myocardial infarction.
Qiao-Mei Wu, Li-Juan Liu, Li-Juan Liu, Teng-Fei Li, Teng-Fei Li, Hai-Wei Deng, Hai-Wei Deng, Jie Li, Jie Li, Yuan-Sheng Zhai, Yuan-Sheng Zhai, Xun Hu, Xun Hu   +12 more
doaj   +1 more source