Results 91 to 100 of about 6,814,669 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Serum Follicular Fluid Growth Differentiation Factor 9 (GDF-9) and Bone Morphogenic Protein 15 (BMP-15) as Markers of Ovarian Reserve [PDF]

Al-Anbar Medical Journal
Background: Growth differentiation factor (GDF-9) and bone morphogenic protein (BMP-15) (GDF-9 co-factor) are proteins that are released by oocytes and control key stages of follicular development and growth.Objectives: To determine the ability of serum ...
Muhjah Hassan, Wasan Abdulhameed
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Assisted reproductive technologies in multiple sclerosis

Репродуктивная эндокринология
Objective of the review: to study the topic of fertility, pregnancy and assisted reproductive technologies (ART) in patients with multiple sclerosis (MS). The analysis of scientific literature in international medical databases was performed. Analysis of
O.D. Shulga, M.I. Hrytsko, A.S. Romaniuk, O.G. Kotsiuba   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

FEATURES OF PREGNANCY COURSE IN WOMEN AFTER APPLICATION OF ASSISTED REPRODUCTIVE TECHNOLOGIES (literature review)

Медична наука України
Background. The problem of infertility remains extremely relevant in modern obstetrics and gynecology practice. In Ukraine, the frequency of infertility in recent years has a constant upward trend and is almost 30%.
V.O. Beniuk, L.M. Vygivska, O.A. Dyndar, N.M. Hychka, V.F. Oleshko, T.V. Ilnytska, T.V. Muliarenko   +6 more
doaj   +1 more source

REPRODUCTIVE TECHNOLOGIES: A READER

, 2004
Acknowledgments -- Editor's introduction -- Ch. 1. Regulation of assisted reproductive technologies in the United States / David Adamson -- Ch. 2. Progress we can be proud of: U.S.
Shannon, Thomas A., ed.
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Kinship in reproductive donation: Anonymity vs openness

RUDN journal of Sociology
Deterioration of reproductive health is one of the pressing issues of our time, and assisted reproductive technologies are increasingly used to address it. However, technological progress has far outpaced social adaptation, complicating the definition of
I. G. Polyakova, A. V. Shvetsova, M. V. Valeeva   +2 more
doaj   +1 more source