Results 51 to 60 of about 171,897 (309)

Menorah Review (No. 47, Fall, 1999) [PDF]

, 1999
Physician-Assisted Suicide -- What Price Prejudice? -- The American Synagogue: Now and Then -- Amelek -- Picks and Pans from the Feminist\u27s Corner -- King David -- A Good Life Now and Then -- Noteworthy ...

core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Planning for the End of Life for People with Dementia - Part 2 [PDF]

, 2011
This publication is a discussion about additional end-of-life options which may become legally available at some time in the future, i.e., assisted death (usually called euthanasia or assisted suicide).
Colleen Cartwright
core   +1 more source

Distinct Biotypes of Visual Perception in Major Depressive Disorder

Advanced Science, EarlyView.
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai, Xi‐Wen Hu, Yuyang Li, Zheng Lin, Yongjie Li, Yong‐Chun Cai, Tao Xu, Ke Jia, Jin‐Fang Han, Zhong‐Lin Tan, Dezhong Yao, Xue Mei Song, Sugai Liang, Georg Northoff   +13 more
wiley   +1 more source

Assisted Suicide in Parkinsonian Disorders

Frontiers in Neurology, 2021
Background: Due to the high prevalence of suicidal ideation in Parkinson's Disease (PD) and exploratory data indicating a similar prevalence in atypical Parkinsonian disorders (APD), we sought to determine the frequency of assisted suicide (AS) as well ...
Georg S. Nuebling, Georg S. Nuebling, Elisabeth Butzhammer, Stefan Lorenzl, Stefan Lorenzl, Stefan Lorenzl   +5 more
doaj   +1 more source

Her Choice, Her Problem: How Having a Choice Can Diminish Family Solidarity [PDF]

, 2011
This Article explores a little-noticed dimension of abortion and assisted suicide (or voluntary euthanasia): how choosing to reject those options can have a negative impact on the legally authorized choosers.
Stith, Richard
core   +2 more sources

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

An argument for physician-assisted suicide and against euthanasia [PDF]

, 2015
The article opens with the hypothesis that the default position that should guide healthcare providers when treating patients at the end-of-life is that patients opt for life. In the absence of an explicit request to die, we may assume that patients wish
Beckford, Bedell, Bernheim, Bilsen, Bilsen, Casarett, Chambaere, Chambaere, Chamber of the Representatives of Belgium, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cook, Cook, Cook, Cook, Culzac, de Diesbach, Delamothe, Deliens, den Hartogh, Gamondi, General Medical Council, Gomez, Haerens, Hardwig, Harris, Hendin, Heneghan, Jochemsen, Keown, Keown, Kuhse, Kuhse, Kuhse, Onwuteaka-Philipsen, Onwuteaka-Philipsen, Pardon, Quebec Bill 52, Schuklenk, Sercu, Sheldon, Singer, Sprung, Steck, Swildens-Rozendaal, van der Heide, van der Heide, van der Heide, van der Wal, Visser   +56 more
core   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source