Results 91 to 100 of about 157,883 (339)

Students with Learning Disabilities: The Effectiveness of Using Assistive Technology [PDF]

open access: yes, 2013
The study focuses on the effectiveness of assistive technology devices and software in helping students with learning disabilities. Students with reading and writing disabilities experience difficulties with literacy tasks throughout the school day. This
Messmer, Andrea
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Assistive Technology, Accommodations, and the Americans with Disabilities Act [PDF]

open access: yes, 2011
This brochure on Assistive Technology, Accommodations, and the Americans with Disabilities Act (ADA) is one of a series on human resources practices and workplace accommodations for persons with disabilities edited by Susanne M. Bruyère, Ph.D., CRC, SPHR,
Bailey, Nell
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

open access: yesFrontiers in Aging Neuroscience
BackgroundCognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly ...
Yin-Hsiang Wang   +4 more
doaj   +1 more source

Biomechanical Evaluation and Strength Test of 3D-Printed Foot Orthoses

open access: yesApplied Bionics and Biomechanics, 2019
Foot orthoses (FOs) are commonly used as interventions for individuals with flatfoot. Advances in technologies such as three-dimensional (3D) scanning and 3D printing have facilitated the fabrication of custom FOs.
Kuang-Wei Lin   +6 more
doaj   +1 more source

User-centered design of a dynamic-autonomy remote interaction concept for manipulation-capable robots to assist elderly people in the home [PDF]

open access: yes, 2012
In this article, we describe the development of a human-robot interaction concept for service robots to assist elderly people in the home with physical tasks.
Arbeiter, Georg   +9 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Age related cognitive impairments and assistive web-base technology [PDF]

open access: yes, 2008
Several researchers argue that age related cognitive impairments have detrimental affect on use of web services by older adults. However little and systematic applied research has been conducted on how age related cognitive impairments might affect the ...
Elliman, T, Lines, L, Money, A
core  

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