Results 111 to 120 of about 160,085 (337)

DESIGN AND ASSISTIVE TECHNOLOGY:

open access: yesErgodesign & HCI, 2016
assistive technology, wheelchair, ArduinoAccessibility is a right, but are still necessary research and development objects that provide the disabled carrying out activities without difficulty.
Roberta Lucas Scatolim   +3 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Future bathroom: A study of user-centred design principles affecting usability, safety and satisfaction in bathrooms for people living with disabilities [PDF]

open access: yes, 2011
Research and development work relating to assistive technology 2010-11 (Department of Health) Presented to Parliament pursuant to Section 22 of the Chronically Sick and Disabled Persons Act ...
Burton, Maria   +3 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Effects of physical training on depression and related quality of life in pre-frail and frail older adults: a systematic review and meta-analysis

open access: yesThe Journal of Nutrition, Health and Aging
Objectives: To investigate the effects of physical training on depression and related quality of life in pre-frail and frail individuals. Design: A systematic review and meta-analysis. Participants: Pre-frail and frail older adults.
Wei-Han Weng   +4 more
doaj   +1 more source

Implications of the Information Technology Revolution for People with Disabilities [PDF]

open access: yes, 2000
The paper focuses on opportunities for the integration of persons with different types of disabilities in the information technology (IT) labour market.
Bonney, Martha   +2 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Curriculum development for nursing and assistive technology [PDF]

open access: yes, 2003
This paper addresses the issue of curriculum innovation and development for nursing education and the inclusion of assistive technology as a subject for student nurses. The paper examines the nurses’ role as part of the interdisciplinary team in creating
Boland, Peter, Corby, Deirdre
core  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

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