Results 81 to 90 of about 8,350,693 (296)

The Provision of Powered Mobility Devices in Italy: Linking Process with Outcomes

open access: yesTechnologies, 2016
The present paper reports on a series of studies conducted at the Regional Center for Assistive Technology (Centro Regionale Ausili, CRA) in Bologna, Italy. Our purpose was to identify a set of internationally validated instruments and a training circuit
Lorenzo Desideri   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Financing assistive technology—Policy options on the path towards universal health coverage

open access: yesFrontiers in Public Health
Supporting functional ability in everyday life is essential for advancing toward universal health coverage (UHC). However, of the estimated 2.5 billion people in need of assistive technology (AT) globally, the vast majority do not have access.
Jens Wilkens   +3 more
doaj   +1 more source

Currency and Competence of Occupational Therapists and Consumers with Rapidly Changing Technology

open access: yesOccupational Therapy International, 2017
Assistive technology was once a specialised field of practice, involving products designed for populations with specific impairments or functional goals.
Emily J. Steel   +3 more
doaj   +1 more source

National priority assistive product list development in low resource countries : lessons learned from Tajikistan

open access: yes, 2021
Introduction: Developing a national assistive products list is an important part of an assistive technology policy and requires knowledge of total population need, and product costs and benefits; information is not always readily available in low-income ...
Allen, Michael   +12 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Effects of motor-cognitive training on cognitive function and gait performance in older adults with dementia: a systematic review and meta-analysis

open access: yesScientific Reports
Motor-cognitive training combines motor and cognitive tasks during the training. So far, its effectiveness on cognitive function and gait in people with dementia remains unknown, and whether it is superior to single physical or cognitive training has yet
Wei-Han Weng   +3 more
doaj   +1 more source

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

open access: yesFrontiers in Aging Neuroscience
BackgroundCognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly ...
Yin-Hsiang Wang   +4 more
doaj   +1 more source

Improving Assistive Technology in Practice: Contributions From Interdisciplinary R&D Collaboration

open access: yes, 2019
This paper describes a collaborative strategy shared by a rehabilitation center and a public university with a goal to improve the knowledge on assistive technology and rehabilitation research and development in Brazil.
da Silva, Sara Raquel Martins   +3 more
core  

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