Results 71 to 80 of about 8,248,213 (296)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Low- to High-Tech Assistive Technology for the Learning Process of Students with Special Needs in Inclusive Classrooms : A Literature Review

Ideguru
This study aims to systematically review the use of assistive technology in the learning process of students with special needs in inclusive classroom settings.
Maringgar Hangesti Putri
doaj   +1 more source

Currency and Competence of Occupational Therapists and Consumers with Rapidly Changing Technology

Occupational Therapy International, 2017
Assistive technology was once a specialised field of practice, involving products designed for populations with specific impairments or functional goals.
Emily J. Steel, Ricky Buchanan, Natasha Layton, Erin Wilson   +3 more
doaj   +1 more source

The Provision of Powered Mobility Devices in Italy: Linking Process with Outcomes

Technologies, 2016
The present paper reports on a series of studies conducted at the Regional Center for Assistive Technology (Centro Regionale Ausili, CRA) in Bologna, Italy. Our purpose was to identify a set of internationally validated instruments and a training circuit
Lorenzo Desideri, Devis Trioschi, Roberta Agusto, Martina Bizzarri, Gianantonio Spagnolin, Sabrina Cantelli, Caterina Paolini, Massimiliano Malavasi, Claudio Bitelli   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Building trust in long-term care settings using assistive technology: a systematic review

Frontiers in Rehabilitation Sciences
BackgroundThis review investigates the dynamics of trust between caregivers and care receivers in long-term care settings, where the implementation of assistive technology also becomes chronically crucial.
Kangjie Zheng, Fred Han, Siyu Yang, Nanxin Li   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

National priority assistive product list development in low resource countries : lessons learned from Tajikistan

, 2021
Introduction: Developing a national assistive products list is an important part of an assistive technology policy and requires knowledge of total population need, and product costs and benefits; information is not always readily available in low-income ...
Allen, Michael, Pupulin, Andrea,, Ekman, Björn,, Pupulin, Andrea, Huber, Manfred,, Ekman, Björn, Khasnabis, Chapal,, Huber, Manfred, Mishra, Satish,, Khasnabis, Chapal, Allen, Michael,, Mishra, Satish, Lund University.   +12 more
core   +1 more source

Effects of motor-cognitive training on cognitive function and gait performance in older adults with dementia: a systematic review and meta-analysis

Scientific Reports
Motor-cognitive training combines motor and cognitive tasks during the training. So far, its effectiveness on cognitive function and gait in people with dementia remains unknown, and whether it is superior to single physical or cognitive training has yet
Wei-Han Weng, Nai-Chen Yeh, Yea-Ru Yang, Ray-Yau Wang   +3 more
doaj   +1 more source