Results 81 to 90 of about 46,885 (304)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Assistive technology as reading interventions for children with reading impairments with a one-year follow-up.

, 2016
This pilot study investigated the possible transfer effect on reading ability in children with reading difficulties after a systematic intervention to train and compensate for reading deficiencies by using applications in smartphones and tablets.
Nilsson, Staffan, Svensson, I., Lindeblad, Emma, Svensson, Idor,, Svensson, Idor, Gustafson, Stefan,, Nilsson, Staffan,, Svensson, I.,, Lindeblad, Emma,, Gustafson, Stefan   +9 more
core   +1 more source

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

Frontiers in Aging Neuroscience
BackgroundCognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly ...
Yin-Hsiang Wang, Yea-Ru Yang, Nai-Chen Yeh, Pei-Yun Li, Ray-Yau Wang   +4 more
doaj   +1 more source

Pushing the limit to near real-time indoor LiDAR-based semantic segmentation [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Semantic segmentation of indoor 3D point clouds is a critical technology for understanding three dimensional indoor environments, with significant applications in indoor navigation, positioning, and intelligent robotics.
P. Bournez, J. Salzinger, M. Cella, F. Vultaggio, F. d’Apolito, P. Fanta-Jende   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving Assistive Technology in Practice: Contributions From Interdisciplinary R&D Collaboration

, 2019
This paper describes a collaborative strategy shared by a rehabilitation center and a public university with a goal to improve the knowledge on assistive technology and rehabilitation research and development in Brazil.
da Silva, Sara Raquel Martins, Medola, Fausto Orsi, Rodrigues, Ana Claudia Tavares, Sandnes, Frode Eika   +3 more
core  

Assistive technology: opportunities and implications [PDF]

, 2009
It is important to recognize the role of technology and the impact on the lives of people who mostly do not understand how much this technology is already shaping the future.
Soar, Jeffrey, Koch, Bill, Horner, Barbara   +2 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source