Results 121 to 130 of about 12,755,297 (284)

Molecular Simulations of the Ribosome and Associated Translation Factors

, 2014
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535), Muhammad Bilal Ashraf (532534), Muhammad Shahab Alhuthali (532536), Tasawar Hayat (433317)   +3 more
core   +6 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prevalence of mental illness and associated factors among the elderly in Ogun East Senatorial District, Nigeria

Archives of Mental Health
Background: Mental health problems are common in the elderly; they often go unnoticed, ignored, untreated, or considered part of normal aging. About a quarter of the Nigerian population have mental health problems, out of which 3.26% are elderly.
Y Omotosho Adebola, O Ogunsemi Olawale, A Fasesan Oluwatoyin, J Sodeinde Kolawole, O Adefala Ngozi, O Ogunkoya John, O Osinaike Abiodun, Amaike Chikwendu, G Ajayi Fisayo, A Abiodun Olumide   +9 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Risk factors of fatigue among community-dwelling older adults in Bahir Dar, Northwest Ethiopia: a community-based cross-sectional study

Frontiers in Public Health
BackgroundFatigue is defined as subjective fatigue and a decline in physical and mental activity that does not improve with rest. Fatigue among older adults could lead to future comorbidity, mortality, decreased social interaction, greater strain on ...
Belayneh Addis Mekuria, Molla Fentanew, Yeshambel Ejigu Anteneh, Jemal Suleman, Yihalem Belet, Kefale Getie, Haimanot Melese, Fiseha Sefiwu Zinabu, Mihret Dejen Takele, Kassahun Cherkos, Assefa Gebeyehu Muluneh, Gashaw Jember Belay   +11 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study

Frontiers in Pediatrics
BackgroundHarmful substance-related infections that cause neonatal deaths on the umbilical stump continue to be a major cause of worry, accounting for a large portion of the yearly mortality toll in developing nations such as Ethiopia.
Misgana Seifu, Sultan Hassen, Mekdim Kassa, Yosef Haile, Zeleke Girma, Temesgen Mohammed Toma, Agune Ashole, Mintesinot Melka Gujo, Wondimagegn Taye Dema, Aleme Mekuriya, Endashaw Shibru   +10 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Prevalence and associated factors of foot self-care practice among diabetic patients in Africa: systematic review and meta-analysis

Frontiers in Endocrinology
IntroductionNowadays, diabetes mellitus is a major global health issue with serious social, economic, and developmental impacts. One of its most severe complications is foot problems. Research shows that poor self-care practices in managing diabetic feet
Yibeltal Assefa Atalay, Bersufekad Wubie Alemie, Kelemu Abebe Gelaw   +2 more
doaj   +1 more source