Results 131 to 140 of about 12,755,297 (284)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The menopausal age and associated factors in Gorgan, Iran [PDF]

, 2013
Background: Considering the physical, emotional and psychological complications of early or delayed menopause on women's life, it is necessary to determine associated factors of menopause age.
Abdollahi, A.A., Ansari, A., Asayesh, H., Mansourian, M., Noroozi, M., Qorbani, M., Rezapour, A., Soleimani, M.A.   +7 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Factors Associated with Unsafe Behavior among Construction Workers in Kupang, East Nusa Tenggara [PDF]

, 2018
Background: Earlier studies have shown that about 90% of accidents in the work settings occur because of unsafe behavior and human errors. If workers do not have the right knowledge, favorable attitude, and proper behavior toward safety measures in a ...
Berek, . C. ( Noorce )
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Lactancia materna ineficaz: prevalencia y factores asociados Ineffective Breastfeeding: prevalence and associated factors

Salud UIS, 2011
Introducción: Es posible evitar muertes neonatales mediante la lactancia materna desde el primer día de vida, pues la leche materna es el alimento óptimo para el lactante por su contenido nutricional necesario favorecer el crecimiento y desarrollo ...
Elvinia Pinilla Gómez, Luis Carlos Orozco V., Fabio A. Camargo F., Erlith Patricia Alfonso H., Ednna Rocío Peña V, Liz Nathalia Villabona A., Yosmery Acevedo G.   +6 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Development and Utilisation of the Chinese Version of Professional Attitude Scale for Nurses: Two Cross‐Sectional Studies

Nursing Open
Aim To translate and assess the psychometric characteristics of the Chinese version of the Professional Attitude Scale for Nurses (PASN‐C) and utilise it to investigate the present status and associated factors of professional attitude among Chinese ...
Siai Zhang, Bingyan Zhao, Cuiwei Lai, Chunmei Zhang, Zhangyi Wang, Yajun Zhang, Jiajia Li, Xuechun Li, Sina Zhang, Tiane Fa   +9 more
doaj   +1 more source