Results 201 to 210 of about 5,741,019 (246)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Evaluation of the turnaround time and the associated factors in computed tomography at the Palestinian hospitals. [PDF]

SAGE Open Med
Rabay'a S, Abu Arrah A, Rabayaa M.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Understanding voice disorders among university staff: prevalence and associated factors. [PDF]

BMC Public Health
Younis FE, Abdelwanees S, El-Domiaty EF, Abdel-Monaem AM, Moussa N, Abdel-Raouf SY.   +5 more
europepmc   +1 more source

The Prevalence of Substance Use Among Students and Associated Factors: A Systematic Review With Narrative Synthesis. [PDF]

Health Sci Rep
Bazleh N.
europepmc   +1 more source

Sexual dysfunction in movement disorders: prevalence, clinical features, associated factors and management. [PDF]

Clin Park Relat Disord
Leclercq V.
europepmc   +1 more source

Prevalence of aggression and its associated factors among medical sciences students. [PDF]

Discov Ment Health
Baloochi A, Askarian M, Mottahedi M, Tavakkol R, Abaszadeh F.   +4 more
europepmc   +1 more source

Examining the length of hospital stay and associated factors in adult patients with schizophrenia. [PDF]

S Afr J Psychiatr
Mahlabane K, Veyej N, Morar T.
europepmc   +1 more source

Coping strategies and associated factors in a sample of Iranian nurses: a cross-sectional study. [PDF]

BMJ Open
Sarvarian A, Tagharrobi Z, Sharifi K, Sooki Z, Zare M.   +4 more
europepmc   +1 more source