Results 111 to 120 of about 1,422,825 (312)
SQ-A: A Collision-triggered Starburst in the Intragroup Medium of Stephan’s Quintet
The Astrophysical JournalWe present new observational evidence supporting the hypothesis that SQ-A, a starburst in the intragroup medium (IGrM) of Stephan’s Quintet (SQ), is triggered by a high-speed collision between two gas systems, one associated with the IGrM ( v ∼ 6900 km ...
C. K. Xu +14 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Various Notions of Associated Prime Ideals
, 1994 Three notions of associated prime ideals, which are equivalent in the noetherian case but differ in the non notherian case, are discussed. Examples illustrate the scope of the notions.
openaire +3 more sources
Associated primes and syzygies of linked modules
Journal of Commutative Algebra, 2019 Motivated by the notion of geometrically linked ideals, we show that over a Gorenstein local ring $R$, if a Cohen-Macaulay $R$-module $M$ of grade $g$ is linked to an $R$-module $N$ by a Gorenstein ideal $c$, such that $Ass_R(M)\cap Ass_R(N)=\emptyset$, then $M\otimes_RN$ is isomorphic to direct sum of copies of $R/a$, where $a$ is a Gorenstein ideal ...
Celikbas, Olgur +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Robust and inducible genome editing via an all-in-one prime editor in human pluripotent stem cells
Nature CommunicationsPrime editing (PE) allows for precise genome editing in human pluripotent stem cells (hPSCs), such as introducing single nucleotide modifications, small insertions or deletions at a specific genomic locus. Here, we systematically compare a panel of prime
Youjun Wu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Towards a communication brain computer interface based on semantic relations.
PLoS ONE, 2014 This article investigates a possible Brain Computer Interface (BCI) based on semantic relations. The BCI determines which prime word a subject has in mind by presenting probe words using an intelligent algorithm.
Jeroen Geuze +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source