Results 121 to 130 of about 471,359 (313)

Immunization with a Modified Vaccinia Virus Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol Primes for an Anamnestic Gag-Specific Cytotoxic T-Lymphocyte Response and Is Associated with Reduction of Viremia after SIV Challenge [PDF]

, 2000
Aruna Seth, Ilnour Ourmanov, Jörn E. Schmitz, Marcelo J. Kuroda, Michelle A. Lifton, Christine E. Nickerson, Linda S. Wyatt, Miles W. Carroll, Bernard Moss, David Venzon, Norman L. Letvin, Vanessa M. Hirsch   +11 more
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The Puzzling Long GRB 191019A: Evidence for Kilonova Light

The Astrophysical Journal
GRB 191019A was a long gamma-ray burst (GRB) lasting ~65 s and, as such, originally thought to be linked to a core-collapse supernova. However, even though follow-up observations identified the optical counterpart close to the bright nucleus of a nearby ...
G. Stratta, A. M. Nicuesa Guelbenzu, S. Klose, A. Rossi, P. Singh, E. Palazzi, C. Guidorzi, A. Camisasca, S. Bernuzzi, A. Rau, M. Bulla, F. Ragosta, E. Maiorano, D. Paris   +13 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

On Berezin norm and Berezin number inequalities for sum of operators

Demonstratio Mathematica
The aim of this study is to obtain several inequalities involving the Berezin number and the Berezin norm for various combinations of operators acting on a reproducing kernel Hilbert space.
Altwaijry Najla, Feki Kais, Minculete Nicusor   +2 more
doaj   +1 more source

The chain property for the associated primes of $\CA$-graded ideals [PDF]

, 2000
Klaus Altmann
openalex   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Asymptotic Growth of Associated Primes of Certain Graph Ideals [PDF]

arXiv, 2012
We specify a class of graphs, $H_t$, and characterize the irreducible decomposition of all powers of the cover ideals. This gives insight into the structure and stabilization of the corresponding associated primes; specifically, providing an answer to the question "For each integer $t\geq 0$, does there exist a (hyper) graph $H_t$ such that ...
arxiv  

The Nef protein of HIV-1 associates with rafts and primes T cells for activation [PDF]

, 2000
Jen-Kuei Wang, Etsuko Kiyokawa, Eric Verdin, Didier Trono   +3 more
openalex   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source