Results 141 to 150 of about 1,422,825 (312)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The chain property for the associated primes of $\CA$-graded ideals [PDF]

, 2000
Klaus Altmann
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

On Berezin norm and Berezin number inequalities for sum of operators

Demonstratio Mathematica
The aim of this study is to obtain several inequalities involving the Berezin number and the Berezin norm for various combinations of operators acting on a reproducing kernel Hilbert space.
Altwaijry Najla, Feki Kais, Minculete Nicusor   +2 more
doaj   +1 more source

On the Crossing of &beta;<SUB>1</SUB>&prime; Martensite Crystals Associated with the Reversible Shape Memory Effect in Cu-Zn-Al Alloys

, 1980
Kazuyoshi Takezawa, Kenji Adachi, Shin rsquo ichi Sato   +2 more
openalex   +2 more sources

Candida albicans Airway Exposure Primes the Lung Innate Immune Response against Pseudomonas aeruginosa Infection through Innate Lymphoid Cell Recruitment and Interleukin-22-Associated Mucosal Response [PDF]

, 2013
Jean Baptiste Mear, Philippe Gosset, Éric Kipnis, Emmanuel Faure, Rodrigue Dessein, Samir Jawhara, Chantal Fradin, Karine Faure, Daniel Poulain, Boualem Sendid, Benoît Guéry   +10 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

On how finite β and three-dimensional magnetic perturbations affect the instability of toroidal ion temperature gradient mode

Nuclear Fusion
The effects of finite $\beta $ (the ratio of plasma kinetic pressure to magnetic pressure) and three-dimensional (3D) magnetic perturbations (MPs) on the instability of toroidal ion temperature gradient (ITG) mode are studied in this work. The expression
Zhangsheng Huang, Weixin Guo, Lu Wang
doaj   +1 more source

Diabetogenic T cells are primed both in pancreatic and gut‐associated lymph nodes in NOD mice [PDF]

, 2003
Ilkka Jaakkola, Sirpa Jalkanen, Arno Hänninen   +2 more
openalex   +1 more source

Associated primes of principal ideals

Duke Mathematical Journal, 1974
Brewer, J. W., Heinzer, W. J.
openaire   +3 more sources