Results 191 to 200 of about 1,422,825 (312)

Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR

, 2001
Charlie Zhong
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Treating RBM20-related cardiomyopathy-Ready for prime time? [PDF]

Mol Ther Nucleic Acids
Kohn J, Lauerer AM, Hegner P, Lebek S.
europepmc   +1 more source

Curbing Their Antagonism: Topics Associated with a Reduction in Personal Attacks at Prime Minister’s Questions

, 2019
Maurice Waddle, Peter Bull
openalex   +2 more sources

Generalized depth and associated primes in the perfect closure $R^\infty$ [PDF]

, 2018
George Whelan
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Investigating and correcting a rare pathogenic mutation in GDF11. [PDF]

HGG Adv
Congdon ST, Bennett J, Opinya R, Agosto AR, Dossias O, Kokko C, Levesque AA, Koob AO, Silver AC, Thomas-Charles CA.   +9 more
europepmc   +1 more source

Analysis of cell-associated DENV RNA by oligo(dT) primed 5’ capture scRNAseq

, 2020
Mark A. Sanborn, Tao Li, Kaitlin Victor, Hayden Siegfried, Christian Fung, Alan L. Rothman, Anon Srikiatkhachorn, Stefan Fernandez, Damon W. Ellison, Richard G. Jarman, Heather Friberg, Irina Maljkovic Berry, Jeffrey R. Currier, Adam T. Waickman   +13 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice. [PDF]

NPJ Vaccines
Sorvillo TE, Karaaslan E, Davies KA, Welch SR, Scholte FEM, Coleman-McCray JD, Aida-Ficken V, Pegan SD, Bergeron É, Montgomery JM, Spiropoulou CF, Spengler JR.   +11 more
europepmc   +1 more source