Results 251 to 260 of about 1,422,825 (312)

Evaluating variants of uncertain significance in adult zebrafish via prime editing: a proof of concept with a COL1A2 variant. [PDF]

BMC Med Genomics
Vanhooydonck M, Debaenst S, Vanbelleghem E, De Saffel H, Syx D, Sips P, Coucke PJ, Willaert A, Callewaert B.   +8 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Exercise Rehabilitation for Heart Failure and Associated Cardiomyopathies. [PDF]

Curr Cardiol Rep
Stahl ME, Weeldreyer NR, MacNamara JP, Lozano PFR, Allen JD.   +4 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Development and Validation of a Brief Age-Normed Screening Tool for Subthreshold Psychosis Symptoms in Youth. [PDF]

Schizophr Bull
Calkins ME, Ered A, Moore TM, White LK, Taylor J, Moxam AB, Ruparel K, Wolf DH, Satterthwaite TD, Kohler CG, Gur RC, Gur RE.   +11 more
europepmc   +1 more source

Prime editing for the investigation of aberrant splicing defect associated with a pathogenic PRPH2 variant

Bruna Lopes da Costa, Katie Helms, Keith Theodore, Yi‐Ting Tsai, Salvatore Marco Caruso, Siyuan Liu, José Ronaldo Lima de Carvalho, Nicholas D. Nolan, Salahaldin A. Tahir, Christopher D. Makinson, Stephen H. Tsang, Peter M. J. Quinn   +11 more
openalex   +1 more source

Associate primes of local cohomology modules over certain quotients of regular rings [PDF]

Tony J. Puthenpurakal
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Low-codimensional associated primes of graded components of local cohomology modules

, 2004
Markus Brodmann, Stefan Fumasoli, Chia S. Lim   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source