Results 261 to 270 of about 1,422,825 (312)

Base and Prime Editing for Inherited Retinal Diseases: Delivery Platforms, Safety, Efficacy, and Translational Perspectives. [PDF]

Pharmaceutics
Zhang H, Li Y, Li J, Li X, Li T.
europepmc   +1 more source

The Work Programme: factors associated with differences in the relative effectiveness of prime providers [PDF]

, 2016
Richard Dorsett, P. Lucchino
openalex  

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model. [PDF]

Front Immunol
Cuenca-Lara P, Blay-Benach M, Cervera Z, Moraleda J, Sevilla IA, Garrido JM, Singh M, López-Soria S, Vidal E, Domingo M, Pérez de Val B.   +10 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry. [PDF]

Vet Q
Snoeck J, Cui X, Vervaeke P, Sanders NN, Garmyn A.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Editorial: CRISPR-Based Genome Editing in Translational Research-2nd Edition. [PDF]

Cells
Xu J, Zhang J, Yang D.
europepmc   +1 more source

Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels

Charlotte C. Bavley, Robert N. Fetcho, Caitlin E. Burgdorf, Alexander P. Walsh, Delaney K. Fischer, Baila S. Hall, Nicole M. Sayles, Natalina H. Contoreggi, Jonathan Hackett, Susan A. Antigua, Rachel Babij, Natalia V. De Marco García, Thomas L. Kash, Teresa A. Milner, Conor Liston, Anjali M. Rajadhyaksha   +15 more
openalex   +1 more source