Results 111 to 120 of about 2,123,683 (269)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Comparing performances of different statistical models and multiple threshold methods in a nested association mapping population of wheat

Frontiers in Plant Science
Nested association mapping (NAM) populations emerged as a multi-parental strategy that combines the high statistical power of biparental linkage mapping with greater allelic richness of association mapping.
Karansher S. Sandhu, Adrienne B. Burke, Lance F. Merrick, Michael O. Pumphrey, Arron H. Carter   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Machine Learning Models for Predicting Professional Disqualification in Peruvian Association Members

Data
The disqualification of licensed professionals for non-payment of their monthly fees constitutes a significant operational risk to the financial sustainability of professional associations.
Manuel Pretel Pretel, Yeny Chávez Llempén, Abel Angel Sullon Macalupu, Paulo Canas Rodrigues, Javier Linkolk López-Gonzales, Esteban Tocto-Cano   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Registered report protocol: Stress testing predictive models of ideological prejudice.

PLoS ONE
In this registered report, we propose to stress-test existing models for predicting the ideology-prejudice association, which varies in size and direction across target groups.
Jordan L Thompson, Abigail L Cassario, Shree Vallabha, Samantha A Gnall, Sada Rice, Prachi Solanki, Alejandro Carrillo, Mark J Brandt, Geoffrey A Wetherell   +8 more
doaj   +1 more source

Enhancing Data Privacy in Large Language Models Through Private Association Editing

Journal of Cybersecurity and Privacy
Large language models (LLMs) require a significant redesign in solutions to preserve privacy in data-intensive applications due to their text-generation capabilities.
Davide Venditti, Elena Sofia Ruzzetti, Giancarlo A. Xompero, Cristina Giannone, Andrea Favalli, Raniero Romagnoli, Fabio Massimo Zanzotto   +6 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling

Scientific Reports
In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for the first time at different temperatures and pressure values ranging from 308 to 338 K and 12 to 30 MPa, respectively.
Seyed Ali Sajadian, Nadia Esfandiari, Adrián Rojas, Salar Hemmati, Abolghasem Jouyban, Gonzalo Aguila, Chandrasekhar Garlapati   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source