Animal Models of Colitis‐Associated Carcinogenesis [PDF]
BioMed Research International, 2011 Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that affect individuals throughout life. Although the etiology and pathogenesis of IBD are largely unknown, studies with animal models of colitis indicate that dysregulation of host/microbial interactions are requisite for the development of IBD. Patients
Kanneganti, Manasa +2 more
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High performance computation of landscape genomic models integrating local indices of spatial association [PDF]
, 2014 Since its introduction, landscape genomics has developed quickly with the increasing availability of both molecular and topo-climatic data. The current challenges of the field mainly involve processing large numbers of models and disentangling selection ...
Bruford, Michael W. +8 more
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Disease model distortion in association studies [PDF]
Genetic Epidemiology, 2011 AbstractMost findings from genome‐wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects.
Vukcevic, D +3 more
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Meta-analysis for genome-wide association studies using case-control design: application and practice [PDF]
Epidemiology and Health, 2016 This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA).
Sungryul Shim +4 more
doaj +1 more source
Asymptotic inference for semiparametric association models
, 2009 Association models for a pair of random elements $X$ and $Y$ (e.g., vectors) are considered which specify the odds ratio function up to an unknown parameter $\bolds\theta$.
Osius, Gerhard
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Four-Weight Spin Models and Jones Pairs [PDF]
, 2001 We introduce and discuss Jones pairs. These provide a generalization and a new approach to the four-weight spin models of Bannai and Bannai.
Chan, Ada +2 more
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Heatmaps for Patterns of Association in log-Linear Models
Socius, 2020 Log-linear models offer a detailed characterization of the association between categorical variables, but the breadth of their outputs is difficult to grasp because of the large number of parameters these models entail.
Mauricio Bucca
doaj +1 more source
Federated generalized linear mixed models for collaborative genome-wide association studies
iScience, 2023 Summary: Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges.
Wentao Li +3 more
doaj +1 more source
Matrix eQTL: Ultra fast eQTL analysis via large matrix operations [PDF]
, 2011 Expression quantitative trait loci (eQTL) mapping aims to determine genomic regions that regulate gene transcription. Expression QTL is used to study the regulatory structure of normal tissues and to search for genetic factors in complex diseases such as
Shabalin, Andrey A.
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A novel computational strategy for DNA methylation imputation using mixture regression model (MRM)
BMC Bioinformatics, 2020 Background DNA methylation is an important heritable epigenetic mark that plays a crucial role in transcriptional regulation and the pathogenesis of various human disorders.
Fangtang Yu +3 more
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