Disease model distortion in association studies [PDF]
Genetic Epidemiology, 2011 AbstractMost findings from genome‐wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects.
Vukcevic, D +3 more
openaire +4 more sources
Animal Models of Hypertension: A Scientific Statement From the American Heart Association
HYPERTENSION, 2019 Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic ...
L. Lerman +12 more
semanticscholar +1 more source
Meta-analysis for genome-wide association studies using case-control design: application and practice [PDF]
Epidemiology and Health, 2016 This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA).
Sungryul Shim +4 more
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A novel computational strategy for DNA methylation imputation using mixture regression model (MRM)
BMC Bioinformatics, 2020 Background DNA methylation is an important heritable epigenetic mark that plays a crucial role in transcriptional regulation and the pathogenesis of various human disorders.
Fangtang Yu +3 more
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Federated generalized linear mixed models for collaborative genome-wide association studies
iScience, 2023 Summary: Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges.
Wentao Li +3 more
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Methodological implementation of mixed linear models in multi-locus genome-wide association studies
Briefings in Bioinformatics, 2017 &NA; The mixed linear model has been widely used in genome‐wide association studies (GWAS), but its application to multi‐locus GWAS analysis has not been explored and assessed.
Y. Wen +9 more
semanticscholar +1 more source
Multivariable association discovery in population-scale meta-omics studies
bioRxiv, 2021 It is challenging to associate features such as human health outcomes, diet, environmental conditions, or other metadata to microbial community measurements, due in part to their quantitative properties. Microbiome multi-omics are typically noisy, sparse
Himel Mallick +19 more
semanticscholar +1 more source
Heatmaps for Patterns of Association in log-Linear Models
Socius, 2020 Log-linear models offer a detailed characterization of the association between categorical variables, but the breadth of their outputs is difficult to grasp because of the large number of parameters these models entail.
Mauricio Bucca
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Egyptian Journal of Medical Human Genetics, 2021 Background Behcet’s disease (BD) is a systemic inflammatory disease of the blood vessels and affects various body parts. This study aimed to determine the association of four single-nucleotide polymorphisms (SNPs) and BD in the Egyptian population using ...
Mohamed M. Emara +5 more
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IMPLEMENTING QUANTITATIVE TECHNIQUES IN ASSESSING THE RISK ATTITUDES [PDF]
Financial Studies, 2021 The financial risk does not only affect the future of a company, but also the dynamic of the economy itself. Therefore, a thorough examination of the risk in the decision-making process of a company represents a substantial aspect. Although research in
Dalis Maria DRĂGHICI
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