Results 201 to 210 of about 1,906,656 (324)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A Multisource Transformer-Guided Graph Representation Learning Framework for circRNA-Disease Association Prediction. [PDF]

ACS Omega
Liang SZ, Wang L, You ZH, Yu CQ.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Association of Cell-Free LncH19 and miR-29b Expression with the PI3K/AKT/HIF-1/VEGF Pathway in Patients with Diabetic Nephropathy: In Silico Prediction and Clinical Validation [PDF]

Noha M. Abd El‐Fadeal, Basma Osman Sultan, Asmaa Kamal Abd-Elmaogood, Essam Al Ageeli, Fatma Tohamy Mekhamer, Sherihan Rohayem, Ahmed Shahidy, Nora Hosny, Manal S. Fawzy, M. Mohsen Ismail, Hidi A. A. Abdellatif   +10 more
openalex   +1 more source

MRDDA: a multi-relational graph neural network for drug-disease association prediction. [PDF]

J Transl Med
Chen C, Zhou Y, Li Y, Xu J, Li D, Wang L.   +5 more
europepmc   +1 more source

Enhancing Genomic Prediction Accuracy with a Single-Step Genomic Best Linear Unbiased Prediction Model Integrating Genome-Wide Association Study Results [PDF]

Zhixu Pang, Wannian Wang, Pu Huang, Hongzhi Zhang, Siying Zhang, Pengkun Yang, Liying Qiao, Jianhua Liu, Yangyang Pan, Kaijie Yang, Wenzhong Liu   +10 more
openalex   +1 more source

25 Prediction of Residual Feed Intake in Feedlot Steers Based on Phenotypic Associations with Feeding Behavior and Carcass Ultrasound Traits. [PDF]

, 2018
Ira L Parsons, Jocelyn R Johnson, William C Kayser, Michael Miller, G. E. Carstens   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A new approach for microbe-disease association prediction: incorporating representation learning of latent relationships. [PDF]

BMC Med Inform Decis Mak
Liu S, Hu W, Wang CC, Zhuo L, Lu X.
europepmc   +1 more source

Additional file 5: of Prediction of lncRNA-disease associations by integrating diverse heterogeneous information sources with RWR algorithm and positive pointwise mutual information

, 2019
Xiao-Nan Fan, Shao‐Wu Zhang, Song-Yao Zhang, Kunju Zhu, Songjian Lu   +4 more
openalex   +1 more source