Results 211 to 220 of about 1,906,656 (324)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

GONNMDA: A Ordered Message Passing GNN Approach for miRNA-Disease Association Prediction. [PDF]

Genes (Basel)
Zeng S, Zhang S, Wang Z, Yang C, Yuan S.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Protein structural domain-disease association prediction based on heterogeneous networks. [PDF]

BMC Genomics
Zhang J, Deng L, Deng L.
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Association prediction of lncRNAs and diseases using multiview graph convolution neural network. [PDF]

Front Genet
Zhang W, Zeng Y, Xiang X, Zhao B, Hu S, Li L, Zhu X, Wang L.   +7 more
europepmc   +1 more source

A Scalable Approach for Short-Term Predictions of Link Traffic Flow by Online Association of Clustering Profiles

, 2020
Alessandro Attanasi, Marco Pezzulla, Luca Simi, Lorenzo Meschini, Guido Gentile   +4 more
openalex   +1 more source

Association of microRNA-221/222 and -323-3p with rheumatoid arthritis via predictions using the human TNF transgenic mouse model [PDF]

, 2012
Ioannis Pandis, Caroline Ospelt, Niki Karagianni, Maria C. Denis, Martin Reczko, Carme Camps, Artemis G. Hatzigeorgiou, Jiannis Ragoussis, Steffen Gay, George Kollias   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Novel Drug-Disease Association Prediction Method Based on Deep Non-Negative Matrix Factorization with Local Graph Feature. [PDF]

Interdiscip Sci
Yang M, Yang B, Chen J, Tang X, Duan G.
europepmc   +1 more source