A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
GiGs: graph-based integrated Gaussian kernel similarity for virus-drug association prediction. [PDF]
Brief BioinformJin Y +7 more
europepmc +1 more source
Inferring Gene-Trait Associations with Diverse Population Gene Expression Prediction Models
, 2020 Elyse Geoffroy, Isabelle Gregga
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iDRKAN: Interpretable miRNA-Disease Association Prediction Based on Dual-Graph Representation Learning and Kolmogorov–Arnold Network [PDF]
Yuefei Zhu +3 more
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ensemble learning based on matrix completion improves microbe-disease association prediction. [PDF]
Brief BioinformChen H, Chen K.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Herb-disease association prediction model based on network consistency projection. [PDF]
Sci RepChen L, Zhang S, Zhou B.
europepmc +1 more source
Prediction of circRNA–Disease Associations via Graph Isomorphism Transformer and Dual-Stream Neural Predictor [PDF]
Hongchan Li +3 more
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