Results 261 to 270 of about 1,960,778 (332)

Genome-Wide Association Study and Genomic Prediction of Soft Wheat End-Use Quality Traits Under Post-Anthesis Heat-Stressed Conditions [PDF]

Dipendra Shahi, Jia Guo, Sumit Pradhan, Muhsin Avci, Guihua Bai, Jahangir Khan, Byung‐Kee Baik, Mohamed Mergoum, Md Ali Babar   +8 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

CDPMF-DDA: contrastive deep probabilistic matrix factorization for drug-disease association prediction. [PDF]

BMC Bioinformatics
Tang X, Hou Y, Meng Y, Wang Z, Lu C, Lv J, Hu X, Xu J, Yang J.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer's disease. [PDF]

J Transl Med
Su YY, Huang HC, Lin YT, Chuang YF, Sheu SY, Lin CC.   +5 more
europepmc   +1 more source

Enhancing Genomic Prediction Accuracy with a Single-Step Genomic Best Linear Unbiased Prediction Model Integrating Genome-Wide Association Study Results [PDF]

Zhixu Pang, Wannian Wang, Pu Huang, Hongzhi Zhang, Siying Zhang, Pengkun Yang, Liying Qiao, Jianhua Liu, Yangyang Pan, Kaijie Yang, Wenzhong Liu   +10 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Circular RNA-Drug Association Prediction Based on Multi-Scale Convolutional Neural Networks and Adversarial Autoencoders. [PDF]

Int J Mol Sci
Wang Y, Lei X, Chen Y, Guo L, Wu FX.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Heterogeneous biomedical entity representation learning for gene-disease association prediction. [PDF]

Brief Bioinform
Meng Z, Liu S, Liang S, Jani B, Meng Z.
europepmc   +1 more source