Results 111 to 120 of about 332,390 (261)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Suprema and infima of association schemes

Discrete Mathematics, 2002
Let \(F\) be a partition of a finite set \(\Omega\). In the vector space \(\mathbb{R}^\Omega\) of all real-valued functions on \(\Omega\), denote by \(F_i\) the characteristic function of the \(i\)th class of \(F\). Then the vectors \(F_i\) form a basis for the subspace \(V_F\) consisting of all real functions which are constant on each class of \(F\).
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Character products of association schemes

Journal of Algebra, 2005
Let \(X\) be a finite set, and \(G\subset X\times X\) an association scheme. For any \(g\in G\) we denote the adjacency matrix of \(g\) by \(\sigma_g\). Let \(\mathbb{C} G=\bigoplus_{g\in G}\mathbb{C}\sigma_g\) -- this is called the adjacency algebra of \(G\) (over \(\mathbb{C}\)).
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Association schemes of quadratic forms

Journal of Combinatorial Theory, Series A, 1985
The author studies a new class of association schemes attached to quadratic forms. These schemes are distance regular (but generally not distance transitive), in terms of graph theory.
openaire   +1 more source

Optimized IRS-Aided UAV Communication for 6G Networks With Phase and User Association Control

IEEE Access
Industry 5.0 relies on advanced automation, high speed connectivity, improved real-time communication support and efficient collaboration to foster an industry ecosystem that is sustainable, innovative and competitive.
Ashu Taneja, Nayef Alqahtani, Ali Alqahtani   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source