Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Living (and work) of Peruvian immigrants in Madrid
Migraciones, 2016 The present article is based on the analysis of the information obtained by means of a statistical analysis of a survey conduct among 110 Peruvian immigrants in Madrid. The living conditions of these workers are presented under a series of headings which
G. Pérez Pérez, S. Veredas Muñoz
doaj
Risk factors associated with the family care of people with serious mental illness. [PDF]
Med Oral Patol Oral Cir Bucal, 2019 Carbonell Á +2 more
europepmc +1 more source
All I Need Is Two: The Clinical Potential of Adding Evaluative Pairing Procedures to Cognitive Behavioral Therapy for Changing Self-, Body- and Food-Related Evaluations. [PDF]
J Clin Med, 2021 Halbeisen G, Paslakis G.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Mediating Role of Migrant Community-Based Organizations: Challenges and Coping Strategies. [PDF]
Voluntas, 2023 Martinez-Damia S +3 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Reconstructing RFT through the Lens of the Interbehavioral Field: What is a Relational Frame Anyway? [PDF]
Perspect Behav SciBarnes-Holmes D +3 more
europepmc +1 more source