Results 71 to 80 of about 484 (253)
Cuadernos de Historia de EspañaLa consideración del asociacionismo como un marco de referencia y expresión, no tan sólo del sentir religioso y de actitudes benéficas sino también como instancia de prácticas sociales vinculadas a la esfera de lo prescripto por los poderes públicos ...
Mariana A. Fábrega
doaj
Utilitarianism: a psychophysical perspective
Paidéia (Ribeirão Preto), 2004 The psychological doctrines of empiricism, associationism, and hedonism served as intellectual sources for the development of utilitarianism in the 18th century and psychophysics in the 19th.
Lawrence Marks
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
piano bAnalyzing the Italian feminist movement of the early 20th century, the historical phenomenon that stands out is that of women's associationism. Studying the aggregation of women's groups allows us to trace a biography of the movement and contributes to ...
Emanuele Carlenzi, Martina Cavalli
doaj +1 more source
San Basilio, storie de Roma: sceneggiatura di una borgata attrice della propria storia
Diacronie. Studi di Storia Contemporanea, 2021 Between 2014 and 2017 a group of members of associationism, activists, and inhabitants of the San Basilio district, north-east of Rome, launchs the public history project San Basilio, storie de Roma with the aim of reconstructing the history of this ...
Alessandro LARUFFA
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source