Results 41 to 50 of about 4,720,061 (265)

Causal associations between risk factors and common diseases inferred from GWAS summary data

Nature Communications, 2017
Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of ...
Zhihong Zhu, Zhili Zheng, Futao Zhang, Yang Wu, M. Trzaskowski, Robert M. Maier, M. Robinson, J. McGrath, P. Visscher, N. Wray, Jian Yang   +10 more
semanticscholar   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

STATISTICAL ESTIMATION OF PRODUCTION FUNCTIONS AND AGRICULTURAL COSTS AND MEASURES OF PRODUCTIVITY EFFICIENCY OF WATER USERS' ASSOCIATIONS OF DIFFERENT IRRIGATION SYSTEMS IN AL-BEHEIRA GOVERNORATE [PDF]

Arab Universities Journal of Agricultural Sciences, 2017
Egypt suffers from future risks due to lack of water especially in the downstream countries, Egypt and Sudan, which depend on the Nile water almost entirely and the upstream countries are moving to raise problems with Egypt and erect dams and pressure on
M. Ibraheim, M. Rehan, H. Sarhan, S. Makled   +3 more
doaj   +1 more source

Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis

Environmental Health Perspectives, 2019
Background: Particulate air pollution’s physical health effects are well known, but associations between particulate matter (PM) exposure and mental illness have not yet been established.
I. Braithwaite, Shuo Zhang, J. Kirkbride, D. Osborn, J. Hayes   +4 more
semanticscholar   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Associativity and Non-Associativity of Some Hypergraph Products [PDF]

Mathematics in Computer Science, 2016
Several variants of hypergraph products have been introduced as generalizations of the strong and direct products of graphs. Here we show that only some of them are associative. In addition to the Cartesian product, these are the minimal rank preserving direct product, and the normal product. Counter-examples are given for the strong product as well as
Richard H. Hammack, Marc Hellmuth, Lydia Ostermeier, Peter F. Stadler   +3 more
openaire   +4 more sources

Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Experimental Neurology, 2019
&NA; Insulin resistance, broadly defined as the reduced ability of insulin to exert its biological action, has been associated with depression and cognitive dysfunction in observational studies.
S. Frangou, M. Shirali, Mark J. Adams, D. M. Howard, J. Gibson, L. Hall, Blair H. Smith, S. Padmanabhan, Alison D Murray, David J. Porteous, C. Haley, I. Deary, Toni‐Kim Clarke, Andrew M. McIntosh   +13 more
semanticscholar   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

PhenoScanner: a database of human genotype–phenotype associations

Bioinform., 2016
Summary: PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of genetic variants with many phenotypes, to help aid ...
James R. Staley, James A. Blackshaw, M. Kamat, Steve Ellis, P. Surendran, Benjamin B. Sun, D. Paul, D. Freitag, S. Burgess, J. Danesh, R. Young, A. Butterworth   +11 more
semanticscholar   +1 more source

From genome-wide associations to candidate causal variants by statistical fine-mapping

Nature reviews genetics, 2018
Advancing from statistical associations of complex traits with genetic markers to understanding the functional genetic variants that influence traits is often a complex process.
D. Schaid, Wenan Chen, N. Larson
semanticscholar   +1 more source