Results 91 to 100 of about 18,540,065 (308)

АКАДЕМИЧЕСКИЙ КОНЦЕПТ «УНИВЕРСИТЕТ» В ЯЗЫКОВОМ СОЗНАНИИ РОССИЙСКИХ И ГЕРМАНСКИХ ПРЕПОДАВАТЕЛЕЙ

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
Актуальность исследуемой проблемы обусловлена, во-первых, значимой позицией, которую занимают академические ценности и основанные на них лингвокультурные концепты в современном мире, во-вторых, интенсификацией русско-немецкой коммуникации в сфере ...
Tatiana Yakovlevna Zaglyadkina
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Concept of TRAITOR in National Consciousness of Native Speakers of Russian and Chinese Languages (according to Data of Associative Experiment)

Научный диалог, 2019
The results of two associative experiments are presented. Russian-speaking respondents were presented with the word-incentive predatel’ ‘traitor,’ Chinese respondents - with the word-incentive 背叛者 (bèipànzhě / traitor).
E. S. Eremkina, E. B. Trofimova
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ETHNO-CULTURAL FEATURES OF STEPFATHER, STEPMOTHER NOMENS DENOTING AN INCOMPLETE RELATIONSHIP IN THE MODERN UKRAINIAN LANGUAGE

Записки з українського мовознавства, 2016
Ethno-cultural features of nominosystem, indicating incomplete kinship discussed in this article on the example of nomenos stepfather, stepmother. Based on the results of free associative experiment revealed ontological associative line of the Ukrainian ...
О. В. Нахапетова
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Psychosemantic Features of Professional Consciousness of Engineers

Психолінгвістика, 2019
This article presents results of an empiric study of psychosemantic features of professional consciousness of engineers: the associative structure of key professional notions has been determined, and its key properties have been revealed.
Olha Drobot
doaj   +1 more source

ASSOCIATIVE FIELD "PANDEMIC": LINGUISTIC EXPERIMENT

, 2022
The research focuses on the peculiarities of the perception of the concept of a pandemic. The article describes a linguistic experiment that made it possible to identify frequency responses to the word pandemic, reflecting the peculiarities of the perception of this concept by different groups of respondents.
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source