Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Associative Experiment as a Method of Interpretation of Discourse
Дискурс Пи, 2018 Discursive space is represented as a fragment of linguistic picture of the world, in which there is an emerging conceptual image, fully manifested in the linguistic consciousness.
G.J. Bogdanovich
doaj +1 more source
Cerebellum to motor cortex paired associative stimulation induces bidirectional STDP-like plasticity in human motor cortex [PDF]
, 2012 The cerebellum is crucially important for motor control and adaptation. Recent non-invasive brain stimulation studies have indicated the possibility to alter the excitability of the cerebellum and its projections to the contralateral motor cortex, with ...
Lu, Ming-Kuei +2 more
core +1 more source
Effects of learning experience on forgetting rates of item and associative memories
Learning & memory (Cold Spring Harbor, N.Y.), 2016 Are associative memories forgotten more quickly than item memories, and does the level of original learning differentially influence forgetting rates? In this study, we addressed these questions by having participants learn single words and word pairs ...
Jiongjiong Yang +7 more
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
«We» in modern linguistic culture (on the material of free associative experiment)
Russian Language Studies, 2013 The article focuses on the structure of the associative field «we» as a fragment of modern linguistic culture. The associative field is modeled on the basis of the free associative experiment.
Y A Fedosova
doaj
Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]
, 2014 With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander +38 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Impact of an Associative Strategy (the PROFO Program) on Small and Medium Enterprises in Chile [PDF]
The main objective of this article is to determine if associative strategies followed in Chile have had any impact on the enhancement of productive performance of Chilean SMEs firms. In order to do that, the estimate of the impact is approached using the
Gustavo Crespi, Jose Miguel Benavente
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source