Results 111 to 120 of about 16,405,289 (331)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Methodology for Trend Research Analysis: Problem Statement

СибСкрипт
If free associative experiments are separated in time, they require a separate methodology. Previous results mean an opportunity for a trend study, provided that the first experiment is replicated under the same conditions and with similar subjects in ...
Elena N. Guts
doaj   +1 more source

The Emergence of Symbol-Based Communication in a Complex System of Artificial Creatures [PDF]

, 2005
We present here a digital scenario to simulate the emergence of self-organized symbol-based communication among artificial creatures inhabiting a virtual world of predatory events. In order to design the environment and creatures, we seek theoretical and
El-Hani, Charbel, Gudwin, Ricardo, Loula, Angelo, Queiroz, João   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Associative dictionary: Methodology of creation and areas of application

Ученые записки Казанского университета: Серия Гуманитарные науки
This article reviews a number of studies pertaining to associative linguography, including those conducted with the use of associative dictionaries. It also examines the current state of interdisciplinary applied research focusing on the associative ...
Yu. A. Volskaya
doaj   +1 more source

Kulinaria w świadomości językowej Polaków, Rosjan i Niemców (aspekt aksjolingwistyczny)

Studia Rossica Posnaniensia, 2018
The article is an attempt at establishing a way of understanding the term Food in the systems of values in the language awareness of Poles, Russians and Germans. The author analyses the results of a Free Word Association Test.
Barbara Rodziewicz
doaj   +1 more source

Revealing frame dynamics through comparing associative fields in diachrony [PDF]

, 2014
The article shows that the changes of an associative field in diachrony can somewhat schematically, but quite accurately reflect the dynamics of the corresponding frame over time.
Miroshnichenko, N. S., Morel Morel, D. A.   +1 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Role of the mesoamygdaloid dopamine projection in emotional learning [PDF]

, 2010
Amygdala dopamine is crucially involved in the acquisition of Pavlovian associations, as measured via conditioned approach to the location of the unconditioned stimulus (US).
AA Grace, AM Murray, AR Wagner, AR Wagner, AR Wagner, BJ Everitt, BJ Everitt, CJ Harmer, CJ Harmer, CW Mueller, DA Powell, E Asan, Emily Salussolia, ES Parker, Gavin D. Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GD Phillips, GE Müller, GJ Mogenson, JA Parkinson, JA Parkinson, JA Rosenkranz, JA Rosenkranz, JL McGaugh, JR Taylor, JV Hinrichs, KA Burke, LJ Freedman, M Fleshler, M McDannald, M Mintz, M Zoli, MT Bardo, NM White, P Blundell, P Blundell, P Holland, P Sokoloff, Paul K. Hitchcott, PJ Lang, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, PK Hitchcott, Q Greba, RA Wise, RC Lennartz, RJ Scibilia, RM Colwill, SB Ostlund, SR Jones, TE Robinson, TE Robinson, TW Robbins, W Schultz   +60 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source