Results 131 to 140 of about 16,405,289 (331)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

ETHNO-CULTURAL FEATURES OF STEPFATHER, STEPMOTHER NOMENS DENOTING AN INCOMPLETE RELATIONSHIP IN THE MODERN UKRAINIAN LANGUAGE

open access: yesЗаписки з українського мовознавства, 2016
Ethno-cultural features of nominosystem, indicating incomplete kinship discussed in this article on the example of nomenos stepfather, stepmother. Based on the results of free associative experiment revealed ontological associative line of the Ukrainian ...
О. В. Нахапетова
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Psychosemantic Features of Professional Consciousness of Engineers

open access: yesПсихолінгвістика, 2019
This article presents results of an empiric study of psychosemantic features of professional consciousness of engineers: the associative structure of key professional notions has been determined, and its key properties have been revealed.
Olha Drobot
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

FREE ASSOCIATIVE EXPERIMENT OF THE WORD “RESPONSIBILITY / 责任” EMBODYING LINGUISTICCONSCIOUSNESS IN MODERN CHINESE STUDENTS

open access: yesPolylinguality and Transcultural Practices, 2016
This article discusses how ethnic and cultural image of «responsibility / 责任» is embodied in linguistic consciousness of Chinese students by means of the free associative experiment, analyzes its associative field,and identify the similarities and ...
Ruishuang Zhu
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

ASSOCIATIVE FIELD "PANDEMIC": LINGUISTIC EXPERIMENT

open access: yes, 2022
The research focuses on the peculiarities of the perception of the concept of a pandemic. The article describes a linguistic experiment that made it possible to identify frequency responses to the word pandemic, reflecting the peculiarities of the perception of this concept by different groups of respondents.
openaire   +1 more source

Mental Association Investigated by Experiment [PDF]

open access: yesThe American Journal of Psychology, 1889
Cattell, J., Bryant, S.
openaire   +2 more sources

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