Results 51 to 60 of about 18,540,065 (308)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

'Library' in the Language Consciousness of Modern Students: from a Book Depository to a Cultural and Educational Hub (Based on a Free Associative Experiment)

University Library at a New Stage of Social Communications Development
Objective. The purpose of the given paper is to record modern students’ perception and interpretation of the library phenomenon, build associative field of the considered stimulus word, and analyze it in details.
M. M. ZHOVNIR, T. O. LESHCHENKO
doaj   +1 more source

Effects of learning experience on forgetting rates of item and associative memories

Learning & memory (Cold Spring Harbor, N.Y.), 2016
Are associative memories forgotten more quickly than item memories, and does the level of original learning differentially influence forgetting rates? In this study, we addressed these questions by having participants learn single words and word pairs ...
Jiongjiong Yang, Lexia Zhan, Yingying Wang, Xiaoya Du, Wenxi Zhou, Xueling Ning, Qing Sun, M. Moscovitch   +7 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Oral Associative Reactions of Russians and Germans to Names of Mental States: Comparative and Quantitative Analysis

Известия Южного федерального университета: Филологические науки, 2020
The article describes a cross-cultural study of associative oral representation of mental states. 32 Russian and 33German students – 53 female and 12 male aged from 20 up to 24 years participated in the research.
Ekaterina M. Alekseeva
doaj   +1 more source

Associative Learning from Replayed Experience [PDF]

, 2017
AbstractWe develop an extension of the Rescorla-Wagner model of associative learning. In addition to learning from the current trial, the new model supposes that animals store and replay previous trials, learning from the replayed trials using the same learning rule. This simple idea provides a unified explanation for diverse phenomena that have proved
Ludvig, Elliot A., Mirian, Mahdieh S., Kehoe, E. James, Sutton, Richard S.   +3 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Taking the Operant Paradigm into the Field: Associative Learning in Wild Great Tits

PLoS ONE, 2015
Associative learning is essential for resource acquisition, predator avoidance and reproduction in a wide diversity of species, and is therefore a key target for evolutionary and comparative cognition research.
J. Morand‐Ferron, Steven Hamblin, E. Cole, L. Aplin, J. Quinn   +4 more
semanticscholar   +1 more source