Results 61 to 70 of about 18,540,065 (308)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The structure of Associative Fields of Stimuli природа / природа / прырода / die Natur in East Slavic and German Languages

open access: yesEast European Journal of Psycholinguistics, 2017
The problem of the relationship between man and nature, society and nature is of current interest for many sciences. Global processes occurring in the world, also due to human activities, increasingly attract attention of community to the ecology ...
Diana Terekhova
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Interrelation Between Conceptual and Linguistic Worldviews (Based on the Economic Lexical Item ‘CLIENT’)

open access: yesПсихолінгвістика, 2019
This article presents a theoretical approach to the concept interpretation “worldview” which expresses human knowledge about environment. The difference between conceptual and linguistic worldviews has been determined.
Lesia Kushmar
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

«We» in modern linguistic culture (on the material of free associative experiment)

open access: yesRussian Language Studies, 2013
The article focuses on the structure of the associative field «we» as a fragment of modern linguistic culture. The associative field is modeled on the basis of the free associative experiment.
Y A Fedosova
doaj  

Associative Experiment as a Method of Interpretation of Discourse

open access: yesДискурс Пи, 2018
Discursive space is represented as a fragment of linguistic picture of the world, in which there is an emerging conceptual image, fully manifested in the linguistic consciousness.
G.J. Bogdanovich
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A thematic group through the prism of verbal associations (based on the material of TG “Supernatural beings”) [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Серия Филология, Журналистика
The article considers the thematic group "Supernatural beings" in the associative-verbal network of Russian native speakers. Russian associative dictionaries, as well as the texts of the Russian National Corpus (the main subcorpus, the period ...
Severina, Ekaterina Alexandrovna
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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