Results 81 to 90 of about 18,540,065 (308)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
НеофилологияINTRODUCTION. The study is devoted to the description of a as one of the effective modern methods of word research, its identification, perception in the linguistic consciousness of a native speaker and reflection of the corresponding ideas about it. The
A. B. Tumanova, I. V. Grigorieva
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Experiments with holographic associative memory
Acta Universitatis Sapientiae, Informatica, 2022 Abstract We reiterate the theoretical basics of holographic associative memory, and conduct two experiments. During the first experiment, we teach the system many associations, while during the second experiment, we teach it only one association. In both cases, the recalling capability of the system is examined from different aspects.
openaire +3 more sources
Learning & memory (Cold Spring Harbor, N.Y.), 2012 In humans recognition memory deficits, a typical feature of diencephalic amnesia, have been tentatively linked to mediodorsal thalamic nucleus (MD) damage.
L. Cross +3 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Associative Field of Linguistic Cultureme Me in Russian Linguistic Consciousness
Russian Language Studies, 2012 This article describes the problem of modeling the structure and content of the linguistic cultureme Me based on the associative field formed during the associative experiment.
Ju A Fedosova
doaj
Kulinaria w świadomości językowej Polaków, Rosjan i Niemców (aspekt aksjolingwistyczny)
Studia Rossica Posnaniensia, 2018 The article is an attempt at establishing a way of understanding the term Food in the systems of values in the language awareness of Poles, Russians and Germans. The author analyses the results of a Free Word Association Test.
Barbara Rodziewicz
doaj +1 more source
Assessing the associative deficit of older adults in long-term and short-term/working memory.
Psychology and Aging, 2012 Older adults exhibit a deficit in associative long-term memory relative to younger adults. However, the literature is inconclusive regarding whether this deficit is attenuated in short-term/working memory.
Tina Chen, M. Naveh-Benjamin
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source