Results 101 to 110 of about 21,364,513 (322)

Genetic associations with educational fields

Nature Genetics
Abstract Educational field choices shape careers, wellbeing and the societal skill distribution, yet genetic influences on what people study remain poorly understood. Here we show that genetic factors are associated with educational field specializations using genome-wide association studies (GWASs) across 463,134
Rosa Cheesman, Ville Anapaz, Sjoerd van Alten, Abdel Abdellaoui, Ralph Porneso, Joakim C. Ebeltoft, Ziada Ayorech, Perline A. Demange, Espen Moen Eilertsen, Agnes Fauske, Alexandra Havdahl, Hannu Lahtinen, Torkild Hovde Lyngstad, Qi Qin, Andrea Ganna, Eivind Ystrom   +15 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Associative structure of the concept Побратим / Sworn Brother in Ukrainian linguistic consciousness

East European Journal of Psycholinguistics
This study examines the concept of побратим (sworn brother) as a linguistic marker of unity, brotherhood, and social consolidation in contemporary Ukrainian consciousness during wartime.
Sofiia Bulyk-Verkhola, Yuliya Tehlivets
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Stability analysis of associative memory network composed of stochastic neurons and dynamic synapses

Frontiers in Computational Neuroscience, 2013
We investigate the dynamical properties of an associative memory network consisting of stochastic neurons and dynamic synapses that show short-term depression and facilitation. In the stochastic neuron model used in this study, the efficacy of the synaptic
Yuichi eKatori, Yuichi eKatori, Yosuke eOtsubo, Masato eOkada, Masato eOkada, Kazuyuki eAihara   +5 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

THE EXPERIENCE OF USING ASSOCIATION EXPERIMENT DATA IN STUDYING A FRAGMENT OF THE LINGUISTIC PICTURE OF THE WORLD

Вестник Кемеровского государственного университета, 2015
The purpose of this work is the construction of the associative field of the concepts TOP/BOTTOM as the objects of designing the liguistic picture of the world in the Chinese and Russian languages, and also the description of the associates included in ...
N. A. Kozlova
doaj  

Elliptic curves associated with simplest quartic fields [PDF]

Journal de théorie des nombres de Bordeaux, 2008
We are studying the infinite family of elliptic curves associated with simplest cubic fields. If the rank of such curves is 1, we determine the whole structure of the Mordell-Weil group and find all integral points on the original model of the curve. Note however, that we are not able to find them on the Weierstrass model if the parameter is even.
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source