Results 111 to 120 of about 19,178,138 (322)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF FRAGMENTS OF RUSSIAN AND ITALIAN LANGUAGE CONSCIOUSNESS

Polylinguality and Transcultural Practices, 2016
The article presents the first results of the free associative experiment and examines the problem of interlingual equivalence between some stimulus words.
T S Elizarova
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Actualization of Interpretational Potential of a Common Noun with Abstract Semantics (based on an Associative Experiment)

Научный диалог
The article proposes the following idea: a word (common noun) is a component of the interpretational activity of the addressee perceiving the lexeme and creating interpretational speech utterance. The language speaker’s association appears as a condensed
E. Yu. Pozdnyakova, N. N. Shpilnaya
doaj   +1 more source

THE IMAGE OF RUSSIA IN THE LANGUAGE CONSCIOUSNESS OF RUSSIAN AND CHINESE STUDENTS ACCORDING TO THE DATA OF ASSOCIATIVE EXPERIMENTS (QUANTITATIVE ANALYSIS)

Многоязычие в образовательном пространстве, 2023
The paper examines the quantitative results of free associative experiments conducted among Russian students and Chinese students studying Russian as a foreign language, with the stimulus word “Russia.” The resulting associates are ordered according to ...
A.B. Antonova, Song Luling
doaj  

Vigabatrin-Associated Visual Field Defects

Pediatric Neurology Briefs, 2001
The prevalence, risk factors, and long-term outcome of vigabatrin-associated visual field defects were examined in 60 adult patients with partial epilepsy treated with vigabatrin for 7 months to 14 years at the University of Kuopio Hospital, Finland.
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Radiation Field Associated with Hiroshima and Nagasaki [PDF]

, 1985
Accuracy of dosimetric estimates can determine the value of the atomic bomb survivor experience in establishing radiation risks. The status of a major revision of this dosimetry, initiated in 1980, is assessed.
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Splitting fields of association schemes

Journal of Combinatorial Theory, Series A, 1991
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source