Results 71 to 80 of about 21,364,513 (322)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Features of Worldview Perception Among Speakers of Yakut and Russian: Associative Field Analysis of Stimulus Words DYOL — SCHASTYE

open access: yesНаучный диалог
This article analyzes the associative fields of the stimulus words DYOL and SCHASTYE, which are central to the linguistic consciousness of Yakut and Russian speakers.
A. P. Vasilyeva
doaj   +1 more source

ETHNOCULTURAL IDIOGLOSSIA AS THE REFLECTION OF THE LITERARY BILINGUALISM IN THE WORKS OF CHINGIZ AITMATOV

open access: yesPolylinguality and Transcultural Practices, 2018
The article, using interdisciplinary and integrated approach presents an analysis of the ethno-cultural idioglossia the “woman” that is central in the ethnic picture of the world of Chingiz Aitmatov.
Nina Leonidovna Chulkina   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Factorization of differential operators, quasideterminants, and nonabelian Toda field equations

open access: yes, 1997
We integrate nonabelian Toda field equations for root systems of types A, B, C, for functions with values in any associative algebra. The solution is expressed via quasideterminants.
Etingof, Pavel   +2 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Anick automorphism of free associative algebras

open access: yes, 2006
We prove that the well-known Anick automorphism of the free associative algebra F over an arbitrary field F of characteristic 0 is wild.Comment: 15 ...
Umirbaev, Ualbai
core   +2 more sources

Vigabatrin-associated visual field defects in children [PDF]

open access: yesEye, 2000
Vigabatrin (Sabril), a drug that blocks GABA transaminase, has been used in the treatment of epilepsy since 1989. There have been reports of irreversible constriction of the visual field in adult patients related to vigabatrin (VGB) therapy, resulting in reduced VGB usage in adults.
I M, Russell-Eggitt   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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