Results 81 to 90 of about 21,364,513 (322)

Interpretative Potential of Abstract and Concrete Common Nouns

СибСкрипт
The article describes the interpretative potential of abstract and concrete common nouns. In interpretational linguistics, any word may become part of dialogue, which means that its semantics is not static.
E Yu. Pozdnyakova, N. N. Shpilnaya
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Vigabatrin associated visual field constriction [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Peripheral visual field defects in patients taking vigabatrin seem to arise in a proportion of patients. Typically a concentric narrowing of the field is seen with preservation of central acuity and colour vision. Case definition remains poorly defined and prevalence figures ranging from as low as 0.14% to as high as 39% have appeared.1 2 The high ...
openaire   +1 more source

Modeling the Evolution of Dynamic Brain Processes During an Associative Learning Experiment

, 2016
We develop a new time series model to investigate the dynamic interactions between the nucleus accumbens and the hippocampus during an associative learning experiment.
M. Fiecas, H. Ombao
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Value Component of American Language Group Consciousness

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2017
The article presents the results of a free associative experiment. The purpose of the experiment was to determine the categorical components of the value system of the American ethnic group at the present stage.
Larisa O. Butakova, Svetlana Yu. Vyazigina   +1 more
doaj   +1 more source

Nilmanifolds and their associated non-local fields [PDF]

Advances in Theoretical and Mathematical Physics, 2020
For six dimensional nilmanifolds we build a module $\mathcal{H}$ of an affine Kac Moody vertex algebras. Then, we associate some logarithmic fields for the module $\mathcal{H}$ and we study their singularities. We also presented a physics motivation behind this construction.
openaire   +2 more sources