Results 141 to 150 of about 11,317,036 (365)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Automophisms of Nil-Triangular Subrings of Algebras Chevalley Type $G_2$ Over Integral Domain. I

Известия Иркутского государственного университета: Серия "Математика"
Let $N\Phi(K)$ be the nil-triangular subalgebra of the Chevalley algebra over an associative commutative ring $K$ with the identity associated with a root system $\Phi$.
A. V. Kazakova
doaj   +1 more source

Rings with Associators in the Commutative Center [PDF]

, 1988
Erwin Kleinfeld
openalex   +1 more source

Supplemental Figure S4 from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma

, 2023
Lisa M. Maurer, Jessica D. Daley, Elina Mukherjee, Rosemarie E. Venier, Claire M. Julian, Nathanael G. Bailey, Michelle F. Jacobs, Chandan Kumar‐Sinha, Haley Raphael, Nivitha Periyapatna, Kurt R. Weiss, Katherine A. Janeway, Rajen Mody, Peter C. Lucas, Linda M. McAllister‐Lucas, Kelly M. Bailey   +15 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On the Structure of Weyl-Type, Witt-Type, and Non-Associative Algebras over Expolynomial Rings

Mathematics
This paper introduces a generalized class of Weyl-type, Witt-type, and non-associative algebras constructed over an exponential–polynomial (expolynomial) framework.
Supriya Sharma, R. S. Raja Durai, Ki-Bong Nam   +2 more
doaj   +1 more source

Resolving the associative learning paradox by category learning in pigeons. [PDF]

Curr Biol, 2023
Wasserman EA, Kain AG, O'Donoghue EM.
europepmc   +1 more source

A non-associative incidence near-ring with a generalized Möbius function

, 2023
John Johnson, Max Wakefield
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Compactifications of $M_{0,n}$ associated with Alexander self-dual complexes: Chow ring, $ψ$-classes and intersection numbers

, 2018
Ilia Nekrasov, Gaiane Panina
openalex   +1 more source