Results 181 to 190 of about 11,317,036 (365)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

On <i>t</i>-derivations of PMS-algebras. [PDF]

open access: yesF1000Res
Melese Kassahun N   +3 more
europepmc   +1 more source

Supplementary Figure 1 from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

open access: gold, 2023
Hiroyuki Nishikawa   +6 more
openalex   +1 more source

Associative Local Function Rings

open access: yes
We prove that for an arbitrary field $k,$ a complete, associative $k^r$-algebra $\hat H$ augmented over $k^r$ has exactly $r$ maximal two-sided ideals and deserves the name $r$-pointed. If $A$ is any $k$-algebra, $M=\{M_i\}_{i=1}^r$ is a family of simple right $A$-modules with a countable $k$-basis, and there is a homomorphism $ρ_A:A\rightarrow\enm_ ...
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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