Enhancing G‐Quadruplex Binding: Rational Design and Biophysical Evaluation of Dimeric Ligands
Fluorescence thermal shift assays, electrospray ionization‐mass spectrometry, CD spectroscopy, molecular modeling and cytotoxicity assays were enrolled to study the binding of a rationally designed anthraquinone‐based G‐quadruplex binder interacting with the nucleic acid as a molecular tweezer.
Matteo Giannangeli +8 more
wiley +1 more source
Racconti al femminile contro il silenzio
Nel vasto campo della memoria post-traumatica negli ultimi anni sono emerse le voci dei ‘figli’, grazie all’insorgere di associazioni, pubblicazioni, talleres, dedicati a figli vissuti senza genitori o in esilio, o con genitori indegni. Non solo figli
Grillo, Rosa Maria
doaj +1 more source
CO-SVILUPPO E INTEGRAZIONE: UNA RICERCA COMPARATA SULL'ASSOCIAZIONISMO GHANESE IN ITALIA E REGNO UNITO [PDF]
Questo lavoro approfondisce lo studio del co-sviluppo inteso come specifica strategia attraverso la quale viene declinato il rapporto migrazione-sviluppo.
MARINI, FRANCESCO
core
The Janus face of group 3 innate lymphoid cells (ILC3s). ILC3s are highly plastic and can adapt their immunoregulatory roles according to the local context, balancing tolerance and activation. Influenced by tissue‐specific environmental cues, they can express MHC class II molecules either alone or jointly with costimulatory molecules, therefore ...
Alessia Calabrò +3 more
wiley +1 more source
Illustrations and associative logic. Short circuits between images of science, art and architecture / Illustrazioni e logiche associative. Cortocircuiti tra immagini della scienza, dell'arte e dell'architettura [PDF]
Le illustrazioni di carattere scientifico non servono solo per veicolare informazioni tra addetti che operano nello stesso ambito all’interno del quale sono concepite e generate.
QUICI, Fabio
core
Constrained variation in the internal architecture of avian wing bones
Read the free Plain Language Summary for this article on the Journal blog. Abstract Extant birds exhibit remarkable ecological disparity accompanied by widespread skeletal convergence driven by functional adaptation. Investigations of morphofunctional associations with ecological factors have frequently focused on the external morphology of avian wing ...
Fabio Alfieri +4 more
wiley +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
The Paradox of Italian Associational Sector: Low Participation, High Innovation [PDF]
Come già ricordato, l’Italia è sempre stata caratterizzata da un livello di partecipazione associativa molto basso, soprattutto se paragonato ad altri Paesi europei.
Bassoli, Matteo +2 more
core
Supporting Patient‐Centred Decisions on Gene Therapy for Haemophilia A: A Conceptual Model
Haemophilia, EarlyView.
Giovanni Di Minno +8 more
wiley +1 more source
TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino +16 more
wiley +1 more source

