Results 211 to 220 of about 24,512 (285)

Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Knowledge of modifiable factors influencing age at onset (AAO) of Alzheimer's disease (AD) remains limited. This study utilizes genetic information to uncover such factors. METHODS Using 43 exposure genome‐wide association studies (GWAS) summary statistics, we calculated corresponding polygenic scores (PGS) for 9219 AD cases and ...
Yi‐Ju Li   +3 more
wiley   +1 more source

Dual Monogenic Cystic Disease Case Report: Autosomal Dominant Polycystic Kidney Disease and Autosomal Dominant Polycystic Liver Disease

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD) are inherited cystic conditions with overlapping features but distinct genetic causes and clinical courses. Here, we report a case of a 50‐year‐old woman with a clinical diagnosis of ADPKD, hypertension, preserved kidney function ...
Anna Katya Brossart   +4 more
wiley   +1 more source

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

open access: yesgenesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu   +10 more
wiley   +1 more source

The impact of rare pathogenic CNVs is exacerbated by assortative mating

open access: yes
Cevallos C   +6 more
europepmc   +1 more source

Demographic Models and Behavioral Assessments Uncover Distinct Species Histories in the Pseudocryptic Nudibranch Genus Hermissenda

open access: yesEcology and Evolution, Volume 16, Issue 2, February 2026.
We reconstructed the speciation history of the recently split pseudocryptic nudibranch genus Hermissenda, finding divergence times in the Pleistocene (1.29–0.55 mya). Demographic modeling and behavioral experiments show no gene flow and assortative mating between sympatric species H. crassicornis (s.s.) and H.
Miranda T. Dennis   +6 more
wiley   +1 more source

Parental haplotypes reconstruction in up to 440,209 individuals reveals recent assortative mating dynamics

open access: yes
Hofmeister RJ   +11 more
europepmc   +1 more source

The Role of Adolescent Mentalizing and Parental Reflective Functioning for Adolescents' Peer Relationships

open access: yesJournal of Adolescence, Volume 98, Issue 2, Page 355-370, February 2026.
ABSTRACT Introduction Given the crucial role peer relationships play for the well‐being of adolescents, it is important to understand the factors that support adolescents' ability to form positive relationships with peers. Within early childhood, both children's mentalizing and parents' ability to reason about their children's mental states relate to ...
Charlotte Aitken   +2 more
wiley   +1 more source

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