Results 101 to 110 of about 5,386,394 (329)

Validating modelling assumptions of alpha particles in electrostatic turbulence

, 2014
To rigorously model fast ions in fusion plasmas, a non-Maxwellian equilibrium distribution must be used. In the work, the response of high-energy alpha particles to electrostatic turbulence has been analyzed for several different tokamak parameters.
Abel, Ian, Dorland, William, Highcock, Edmund, Wilkie, George   +3 more
core   +1 more source

An introduction to instrumental variable assumptions, validation and estimation

Emerging Themes in Epidemiology, 2018
The instrumental variable method has been employed within economics to infer causality in the presence of unmeasured confounding. Emphasising the parallels to randomisation may increase understanding of the underlying assumptions within epidemiology.
M. L. Lousdal
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The interrelatedness between the Nama Khoikhoi supreme being and celestial objects

HTS Teologiese Studies/Theological Studies
The assumption among Europeans that the Khoikhoi indigenous people of southern Africa had little to no religious beliefs is evident throughout historical documents.
Iwana Hartmann, Maniraj Sukdaven
doaj   +1 more source

Experimental precision in corn trials using the Papadakis method Precisão experimental dos ensaios de milho pelo método de Papadakis

Ciência e Agrotecnologia, 2010
The objective of this work was to verify whether the use of the Papadakis method in competing corn hybrid trials would lead to modifications in the validity of assumptions for the mathematical model of variance analysis and for experimental precision ...
Lindolfo Storck, Sidinei José Lopes, Alberto Cargnelutti Filho, Alessandro Dal'Col Lúcio, Marcos Toebe   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Utilização do método de Papadakis na melhoria da qualidade experimental de ensaios com soja Use of the Papadakis method to improve soybean trial quality

Pesquisa Agropecuária Brasileira, 2008
O trabalho teve como objetivo verificar as modificações na análise estatística, em relação ao atendimento aos pressupostos do modelo matemático e aos diferentes indicadores de precisão, que podem ser atribuídas à aplicação do método de Papadakis, na ...
Lindolfo Storck, Cleiton Steckling, Teresinha Roversi, Sidinei José Lopes   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

"The Reason I Jump" by Naoki Higashida: A Reconsideration of Autism, Empathy, and “Mind-Blindness”

Voices in Bioethics, 2016
The field of bioethics has the potential to contribute to a better understanding of how the medical and social assumptions that accompany diagnostic categories impact the people who have been diagnosed.
Sara Bergstresser
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source