Results 41 to 50 of about 1,651 (200)
Advances in targeted Alpha therapy for prostate cancer [PDF]
, 2019 BACKGROUND: Amongst therapeutic radiopharmaceuticals, targeted alpha therapy (TαT) can deliver potent and local radiation selectively to cancer cells as well as the tumor microenvironment and thereby control cancer while minimizing toxicity.
De Vincentis, G +11 more
core +2 more sources
Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”
Pharmaceutics, 2021 Among all existing radionuclides, only a few are of interest for therapeutic applications and more specifically for targeted alpha therapy (TAT). From this selection, actinium-225, astatine-211, bismuth-212, bismuth-213, lead-212, radium-223, terbium-149
Romain Eychenne +4 more
doaj +1 more source
Microdosimetry of radiohalogens in thyroid models [PDF]
, 2014 The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to ...
Josefsson, Anders
core +1 more source
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]
, 2019 Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J. +10 more
core +2 more sources
Molecules, 2019 During the purification of radioisotopes, decay periods or time dependent purification steps may be required to achieve a certain level of radiopurity in the final product.
Jonathan Fitzsimmons +4 more
doaj +1 more source
Gene expression signature in mouse thyroid tissue after 131I and 211At exposure [PDF]
, 2015 BACKGROUND: (131)I and (211)At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile variations, assess the impact on cellular activity, and
Britta Langen +6 more
core +1 more source
Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab [PDF]
, 2011 Background The aim of the present study was to explore the biodistribution, normal tissue toxicity, and therapeutic efficacy of the internalizing low-dose rate alpha-particle-emitting radioimmunoconjugate 227Th-trastuzumab in mice with ...
Abbas, Nasir +5 more
core +1 more source
Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics [PDF]
, 2010 Background Early studies have demonstrated comparable levels of HER2/ErbB2 expression in both breast and ovarian cancer. Trastuzumab (Herceptin), a therapeutic monoclonal antibody directed against HER2, is FDA-approved for the treatment of both early and
Jason A Wilken +2 more
core +3 more sources
Scientific Reports, 2021 Astatine-211 (211At)-labeled phenylalanine is expected to be a promising agent for targeted alpha-particle therapy for the treatment of patients with glioma.
Yoshifumi Shirakami +11 more
doaj +1 more source
Corrosion behavior of iron-chrome alloys in liquid bismuth
Mechanical Engineering Journal, 2022 For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, we have proposed the innovative “Liquid Bismuth Target System.” The target window in this system must be made from a material that resists the highly corrosive
Toshihide TAKAI +3 more
doaj +1 more source