Results 71 to 80 of about 1,651 (200)

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

In vivo stable 211At-labeled prostate-specific membrane antigen-targeted tracer using a neopentyl glycol structure

EJNMMI Radiopharmacy and Chemistry
Background Prostate cancer is a common cancer among men worldwide that has a very poor prognosis, especially when it progresses to metastatic castration-resistant prostate cancer (mCRPC).
Hiroyuki Suzuki, Kento Kannaka, Mizuki Hirayama, Tomoki Yamashita, Yuta Kaizuka, Ryota Kobayashi, Takahiro Yasuda, Kazuhiro Takahashi, Tomoya Uehara   +8 more
doaj   +1 more source

Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking [PDF]

, 2019
In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211 At-labeled radiopharmaceuticals.
Aneheim, Emma, Denk, Christoph, Herth, Matthias M., Jensen, Holger, Lindegren, Sture, Mikula, Hannes, Wilkovitsch, Martin   +6 more
core   +1 more source

Process for producing astatine-211 for radiopharmaceutical use

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1988
A process for reliably and consistently producing astatine-211 in small controlled volumes of a solution, which is selected from a choice of solvents that are useful in selected radiopharmaceutical procedures in which the At-211 activities are to be applied.
Saed Mirzadeh, Richard M. Lambrecht
openaire   +1 more source

Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Exercise testing has long been essential for evaluating diagnosis, prognosis, and functional status in pulmonary hypertension (PH). Recent advances have clarified its role in defining reference values and prognostic markers. Nonetheless, substantial knowledge gaps persist regarding the implementation of invasive cardiopulmonary exercise ...
Aaron B. Waxman, Abraham Samuel Babu, Roberto Badagliacca, Eloara Ferreira, Patty George, Marco Guazzi, Luke Howard, Darlene Kim, Gabor Kovacs, Saad Kubba, David Langleben, Colm McCabe, Thais Menezes, Rudolf Oliveira, Stylianos Orfanos, Inderjit Singh, David Systrom, Ryan Tedford, Rebecca Vanderpool, Carmine Dario Vizza, Franz P. Rischard   +20 more
wiley   +1 more source

Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab [PDF]

, 2018
This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide.
Beyer, G.-J, Buchegger, F., Hartley, O., Künzi, G., Miederer, M., Senekowitsch-Schmidtke, R., Soloviev, D., Vranješ-Đurić, S., Čomor, J.   +8 more
core  

SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995 [PDF]

, 1995
Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed ...
Jaszczak, R.J.
core   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Production and Distillation of the Therapeutic Radionuclide Astatine-211 at the Texas A&M Cyclotron Institute [PDF]

, 2018
The use of the alpha particle emitting radionuclide ²¹¹At for clinical therapy of primary and metastatic tumors via targeted methods is an attractive modality for increasing cancer management and survivability.
Martin, Thomas Michael
core   +3 more sources

Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

Applied Sciences, 2013
A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1) dissolution of bismuth target in conc.
Shigeki Watanabe, D. Scott Wilbur, Sujit Pal, Ming-Kuan Chyan, Ethan R. Balkin, Donald K. Hamlin, Katherine Gagnon   +6 more
doaj   +1 more source