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The Lancet, 2018 Asthma-one of the most common chronic, non-communicable diseases in children and adults-is characterised by variable respiratory symptoms and variable airflow limitation. Asthma is a consequence of complex gene-environment interactions, with heterogeneity in clinical presentation and the type and intensity of airway inflammation and remodelling.
A. Papi +3 more
semanticscholar +9 more sources
Epidemiology of Asthma in Children and Adults
Frontiers in Pediatrics, 2019 Asthma is a globally significant non-communicable disease with major public health consequences for both children and adults, including high morbidity, and mortality in severe cases.
Adnan Custovic, Jennifer L Perret
exaly +2 more sources
Epithelial cell dysfunction, a major driver of asthma development
Allergy: European Journal of Allergy and Clinical Immunology, 2020 Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair ...
Darryl A Knight +2 more
exaly +2 more sources
Allergy, Asthma & Clinical Immunology, 2011 Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions.
Kim, Harold L., Mazza, Jorge
openaire +7 more sources
Nature Reviews Disease Primers, 2015 Asthma is the most common inflammatory disease of the lungs. The prevalence of asthma is increasing in many parts of the world that have adopted aspects of the Western lifestyle, and the disease poses a substantial global health and economic burden. Asthma involves both the large-conducting and the small-conducting airways, and is characterized by a ...
Holgate, Stephen T. +5 more
openaire +8 more sources
Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes
European Respiratory Journal, 2021 The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually updated evidence-based strategy for asthma management and prevention, which can be adapted for local circumstances (e.g. medication availability).
H. Reddel +20 more
semanticscholar +1 more source
Research Involvement and Engagement, 2023 Plain English summary There are more Black people with asthma in the US than White people. Black people have more hospital stays or deaths from asthma than White people. This highlights the need for Black people to be involved in research.
LeRoy Graham +6 more
doaj +1 more source
BMC Pediatrics, 2023 Background Air pollution harms health across the life course. Children are at particular risk of adverse effects during development, which may impact on health in later life.
Ivelina Tsocheva +36 more
doaj +1 more source
Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.
New England Journal of Medicine, 2021 BACKGROUND Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma.
A. Menzies-Gow +13 more
semanticscholar +1 more source