Results 91 to 100 of about 991,775 (377)

Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators

Advanced Science, EarlyView.
There are many limitations of conventional corticosteroids in the treatment of respiratory inflammation. Here, a multifunctional 2D nanoplatform is designed that simultaneously targets cfDNA, NETs, RONS, and bacterial infection. The nanoplatforms exhibited excellent therapeutic efficacy in vivo and could serve as a new therapeutic approach for severe ...
Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu   +12 more
wiley   +1 more source

“Unidos Hablemos” – description of a virtual conference series to engage the Hispanic and Latino community in asthma and COVID-19 education and research

Research Involvement and Engagement
Background Inequity in asthma and COVID-19 outcomes and research among Hispanic or Latino individuals is well established. Patient centered outcomes research (PCOR) may help address these inequalities.
Vivian Hernandez-Trujillo, Mary Hart, Rose Marie Ramos, Lynda Mitchell, Alex Colon Moya, Dorothy Delarosa, Margie Lorenzi, Marcela Gieminiani, Donna D. Gardner   +8 more
doaj   +1 more source

Analysis of Error-prone Electronic Health Records with Multi-wave Validation Sampling: Association of Maternal Weight Gain during Pregnancy with Childhood Outcomes [PDF]

arXiv, 2021
Electronic health record (EHR) data are increasingly used for biomedical research, but these data have recognized data quality challenges. Data validation is necessary to use EHR data with confidence, but limited resources typically make complete data validation impossible.
arxiv  

Occupational Asthma or Work-Related Exacerbation of Asthma [PDF]

, 2019
[Excerpt] Occupational asthma is asthma due to work exposures. It can be caused by a specific workplace agent with a specific immune system response – the agent is called a sensitizer.
Brown, Nellie J
core   +1 more source

(Correcting) misdiagnoses of asthma: A cost effectiveness analysis [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Amanda Sumner, BN Awadh, Douglas Coyle, HM Sharpe, K Bahadori, Katherine Vandemheen, KB Weiss, L McKnight-Eily, LC O'Dowd, MD Krahn, MG Cisternas, MK Campbell, Ontario Drug Benefit Formulary/Comparative Drug Index, P Kenny, R Jin, RB Haynes, S Diaz-Lobato, S Kamble, SD Aaron, Shawn Aaron, Smita Pakhale, SP Corrigan, Statistics Canada, VP Luks, WJ Ungar   +24 more
core   +4 more sources

Occupational asthma.

Environmental Health Perspectives, 1986
Many toxic compounds found in air emissions may induce bronchoconstriction. In the workplace, workers are exposed to these compounds, often in much higher concentrations. Some of these compounds act as sensitizers. Of these, some compounds induce asthma by producing specific IgE antibodies to the compound or its protein conjugate, while others induce ...
openaire   +4 more sources

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Multiple electrolyte imbalances and mixed acid-base disorder posing a diagnostic dilemma: a case report

Journal of Medical Case Reports, 2020
Background In clinical practice, both the history and laboratory testing are paramount to making an accurate diagnosis. Situations in which laboratory findings and patient history are not congruent pose a diagnostic dilemma.
Fortune O. Alabi, Christopher O. Alabi, Rafaela G. Basso, Nadia Lakhdar, Adebanke O. Oderinde   +4 more
doaj   +1 more source

Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Advanced Science, EarlyView.
This study reveals that in alveolar macrophages of high‐fat diet‐induced obese mice, the transcriptional repressor GFI1 is upregulated. This upregulation suppresses ACOD1 expression, which intensifies lipopolysaccharide‐induced lung inflammation and oxidative stress, thereby worsening acute lung injury. Abstract To investigate the mechanisms behind the
Jingyue Ma, Yichan Ao, Zhen Yue, Zhiqiao Wang, Xiangyu Hou, Hongbin Li, Hanbing Wang, Siqing Luo, Jianyu He, Zikun Duan, Ling Liu, Ke Wei   +11 more
wiley   +1 more source